Synergistic antioxidant and antibacterial activity of curcumin-C3 encapsulated chitosan nanoparticles

Desu N.K. Reddy, Fu Yung Huang, Shao Pin Wang, Ramya Kumar

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Background: Recent studies have focused on the nanoformulations of curcumin to enhance its solubility and bioavailability. The medicinal properties of curcumin-C3 complex, which is a combination of three curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored. Objective: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize and evaluate their antioxidant and antibacterial potential. Methods: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and nanoparticle tracking analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities. Results: Curcumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of >90%, drug release and improved antioxidant potential. Moreover, curcumin-C3-chitosan nanoparticle showed stronger inhibition of Escherichia coli and Staphylococcus aureus. Conclusion: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system in the treatment of inflammatory and bacterial diseases.

Original languageEnglish
Pages (from-to)5021-5029
Number of pages9
JournalCurrent Pharmaceutical Design
Issue number39
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery


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