Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

Jih Ru Hwu; Shwu Chen Tsay; Kao Shu Chuang; Mohit Kapoor; Jia Yu Lin; Chen Sheng Yeh; Wu Chou Su; Ping Ching Wu; Tsung Lin Tsai; Pei Wen Wang; Dar Bin Shieh

doi:10.1002/chem.201504915

Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

Jih Ru Hwu, Shwu Chen Tsay, Kao Shu Chuang, Mohit Kapoor, Jia Yu Lin, Chen Sheng Yeh, Wu Chou Su, Ping Ching Wu, Tsung Lin Tsai, Pei Wen Wang, Dar Bin Shieh

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10 Citations (Scopus)

Abstract

Platinum(II)-sulindac complexes [{η²-C₅H₄SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η²-C₅H₄SN(O)}PtCl{(S=O)Sulindac}], [{η²-C₅H₄SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η²-C₅H₄SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC₅₀ values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η²-C₅H₄SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of Pt^II-sulindac complexes were synthesized that exhibited remarkable IC₅₀ values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

Original language	English
Pages (from-to)	1926-1930
Number of pages	5
Journal	Chemistry - A European Journal
Volume	22
Issue number	6
DOIs	https://doi.org/10.1002/chem.201504915
Publication status	Published - 2016 Feb 5

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Organic Chemistry

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@article{f5c5a3bb19c04330a982aa4a767a56d9,

title = "Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs",

abstract = "Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.",

author = "Hwu, {Jih Ru} and Tsay, {Shwu Chen} and Chuang, {Kao Shu} and Mohit Kapoor and Lin, {Jia Yu} and Yeh, {Chen Sheng} and Su, {Wu Chou} and Wu, {Ping Ching} and Tsai, {Tsung Lin} and Wang, {Pei Wen} and Shieh, {Dar Bin}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2016",

month = feb,

day = "5",

doi = "10.1002/chem.201504915",

language = "English",

volume = "22",

pages = "1926--1930",

journal = "Chemistry - A European Journal",

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TY - JOUR

T1 - Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

AU - Hwu, Jih Ru

AU - Tsay, Shwu Chen

AU - Chuang, Kao Shu

AU - Kapoor, Mohit

AU - Lin, Jia Yu

AU - Yeh, Chen Sheng

AU - Su, Wu Chou

AU - Wu, Ping Ching

AU - Tsai, Tsung Lin

AU - Wang, Pei Wen

AU - Shieh, Dar Bin

PY - 2016/2/5

Y1 - 2016/2/5

N2 - Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

AB - Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

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Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

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