Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

Jih Ru Hwu, Shwu Chen Tsay, Kao Shu Chuang, Mohit Kapoor, Jia Yu Lin, Chen Sheng Yeh, Wu Chou Su, Ping Ching Wu, Tsung Lin Tsai, Pei Wen Wang, Dar Bin Shieh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

Original languageEnglish
Pages (from-to)1926-1930
Number of pages5
JournalChemistry - A European Journal
Volume22
Issue number6
DOIs
Publication statusPublished - 2016 Feb 5

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Sulindac
Platinum
Cells
Nanoparticles
Pharmaceutical Preparations
Acids
Dimethyl Sulfoxide
Thymidine
Milk

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

Cite this

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title = "Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs",
abstract = "Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.",
author = "Hwu, {Jih Ru} and Tsay, {Shwu Chen} and Chuang, {Kao Shu} and Mohit Kapoor and Lin, {Jia Yu} and Yeh, {Chen Sheng} and Su, {Wu Chou} and Wu, {Ping Ching} and Tsai, {Tsung Lin} and Wang, {Pei Wen} and Shieh, {Dar Bin}",
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month = "2",
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doi = "10.1002/chem.201504915",
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pages = "1926--1930",
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Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs. / Hwu, Jih Ru; Tsay, Shwu Chen; Chuang, Kao Shu; Kapoor, Mohit; Lin, Jia Yu; Yeh, Chen Sheng; Su, Wu Chou; Wu, Ping Ching; Tsai, Tsung Lin; Wang, Pei Wen; Shieh, Dar Bin.

In: Chemistry - A European Journal, Vol. 22, No. 6, 05.02.2016, p. 1926-1930.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

AU - Hwu, Jih Ru

AU - Tsay, Shwu Chen

AU - Chuang, Kao Shu

AU - Kapoor, Mohit

AU - Lin, Jia Yu

AU - Yeh, Chen Sheng

AU - Su, Wu Chou

AU - Wu, Ping Ching

AU - Tsai, Tsung Lin

AU - Wang, Pei Wen

AU - Shieh, Dar Bin

PY - 2016/2/5

Y1 - 2016/2/5

N2 - Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

AB - Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

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