Synthesis and antiplatelet activity of 3,5,6,7,8,2',3' and 4'- monosubstituted 2-phenyl-4-quinolones

Ming Chieh Hsieh, Li Jiau Huang, Kuo Hsiung Lee, Tian Shung Wu, Sheng Chih Chen, Che Ming Teng, Sheng Chu Kuo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In a continuation of our search for novel antiplatelet agents, a series of 3,5,6,7,8,2',3' and 4'-monosubstituted derivatives of 2-phenyl-4-quinolone were synthesized and their inhibitory effects against arachidonic acid (AA)- induced platelet aggregation were evaluated. Although no regular or definite structure-activity relationships were observed, some compounds exhibited significant inhibitory activity. Among them, 5-ethyl-2-phenyl-4-quinolone (19) displayed the highest potency, outperformed indomethacin, and was chosen as a lead compound for structural modification.

Original languageEnglish
Pages (from-to)67-80
Number of pages14
JournalChinese Pharmaceutical Journal
Issue number2
Publication statusPublished - 1998 Apr

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science


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