Synthesis and antiplatelet activity of 3,5,6,7,8,2',3' and 4'- monosubstituted 2-phenyl-4-quinolones

Ming Chieh Hsieh, Li Jiau Huang, Kuo Hsiung Lee, Tian Shung Wu, Sheng Chih Chen, Che Ming Teng, Sheng Chu Kuo

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4 Citations (Scopus)

Abstract

In a continuation of our search for novel antiplatelet agents, a series of 3,5,6,7,8,2',3' and 4'-monosubstituted derivatives of 2-phenyl-4-quinolone were synthesized and their inhibitory effects against arachidonic acid (AA)- induced platelet aggregation were evaluated. Although no regular or definite structure-activity relationships were observed, some compounds exhibited significant inhibitory activity. Among them, 5-ethyl-2-phenyl-4-quinolone (19) displayed the highest potency, outperformed indomethacin, and was chosen as a lead compound for structural modification.

Original languageEnglish
Pages (from-to)67-80
Number of pages14
JournalChinese Pharmaceutical Journal
Volume50
Issue number2
Publication statusPublished - 1998 Apr

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Hsieh, M. C., Huang, L. J., Lee, K. H., Wu, T. S., Chen, S. C., Teng, C. M., & Kuo, S. C. (1998). Synthesis and antiplatelet activity of 3,5,6,7,8,2',3' and 4'- monosubstituted 2-phenyl-4-quinolones. Chinese Pharmaceutical Journal, 50(2), 67-80.