In a continuation of our search for novel antiplatelet agents, a series of 3,5,6,7,8,2',3' and 4'-monosubstituted derivatives of 2-phenyl-4-quinolone were synthesized and their inhibitory effects against arachidonic acid (AA)- induced platelet aggregation were evaluated. Although no regular or definite structure-activity relationships were observed, some compounds exhibited significant inhibitory activity. Among them, 5-ethyl-2-phenyl-4-quinolone (19) displayed the highest potency, outperformed indomethacin, and was chosen as a lead compound for structural modification.
|Number of pages||14|
|Journal||Chinese Pharmaceutical Journal|
|Publication status||Published - 1998 Apr|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science