Synthesis and antiproliferative evaluation of 4-anilino-n-methoxyfurol[2,3-b]quinoline derivates (n=6, 7). Part 5

Yeh Long Chen, Huan Chin Lin, Chia Ning Yang, Pei-Jung Lu, Cherng Chyi Tzeng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of 27 differently substituted 4-anilinofuro]2,3-b]quinolines were synthesized and evaluated for their antiproliferative activities against the HeLa, SKHep1, SAS, AGS, A549, and CE81T cell lines, cancers commonly found in Asian countries. Among the compounds tested, 1-4-[(3-chloro-7-methoxyfure [2,3-b]quinolin-4-yl) amino]phenyl)ethanone (1) was the most potent, with IC50 values of 3.1,3.0, and 4.2 μm, resp., against the growth of HeLa, SKHep, and CE81T cells. Compound 1 was, thus, further evaluated by flow cytometry to evaluate its effect on the cell-cycle distribution of HeLa cells. Our results indicated that 1 readily induces cell-cycle arrest in the G2/M phase, followed by DNA fragmentation and, ultimately, cell death.

Original languageEnglish
Pages (from-to)267-278
Number of pages12
JournalChemistry and Biodiversity
Volume5
Issue number2
DOIs
Publication statusPublished - 2008 Dec 1

Fingerprint

Quinolines
G2 Phase
DNA Fragmentation
Cell Cycle Checkpoints
HeLa Cells
Cell Division
Inhibitory Concentration 50
Cell Cycle
Flow Cytometry
Cell Death
Cells
Growth
Neoplasms
Flow cytometry
Cell death
DNA
A549 Cells
quinoline

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

Cite this

Chen, Yeh Long ; Lin, Huan Chin ; Yang, Chia Ning ; Lu, Pei-Jung ; Tzeng, Cherng Chyi. / Synthesis and antiproliferative evaluation of 4-anilino-n-methoxyfurol[2,3-b]quinoline derivates (n=6, 7). Part 5. In: Chemistry and Biodiversity. 2008 ; Vol. 5, No. 2. pp. 267-278.
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Synthesis and antiproliferative evaluation of 4-anilino-n-methoxyfurol[2,3-b]quinoline derivates (n=6, 7). Part 5. / Chen, Yeh Long; Lin, Huan Chin; Yang, Chia Ning; Lu, Pei-Jung; Tzeng, Cherng Chyi.

In: Chemistry and Biodiversity, Vol. 5, No. 2, 01.12.2008, p. 267-278.

Research output: Contribution to journalArticle

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