Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh, Hsueh Yun Lee, Chih Ying Nien, Ching Chuan Kuo, Chi Yen Chang, Jang-Yang Chang, Jing Ping Liou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

Original languageEnglish
Pages (from-to)2274-2284
Number of pages11
JournalMolecules
Volume16
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

cultured cells
Antineoplastic Agents
cancer
Cells
Cell Line
evaluation
synthesis
Inhibitory Concentration 50
Neoplasms
analogs
Growth
combretastatin

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Hsieh, Cheng Chih ; Lee, Hsueh Yun ; Nien, Chih Ying ; Kuo, Ching Chuan ; Chang, Chi Yen ; Chang, Jang-Yang ; Liou, Jing Ping. / Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents. In: Molecules. 2011 ; Vol. 16, No. 3. pp. 2274-2284.
@article{2a42d4ee0d7d4a238c96cab39a2973f3,
title = "Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents",
abstract = "A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.",
author = "Hsieh, {Cheng Chih} and Lee, {Hsueh Yun} and Nien, {Chih Ying} and Kuo, {Ching Chuan} and Chang, {Chi Yen} and Jang-Yang Chang and Liou, {Jing Ping}",
year = "2011",
month = "3",
day = "1",
doi = "10.3390/molecules16032274",
language = "English",
volume = "16",
pages = "2274--2284",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents. / Hsieh, Cheng Chih; Lee, Hsueh Yun; Nien, Chih Ying; Kuo, Ching Chuan; Chang, Chi Yen; Chang, Jang-Yang; Liou, Jing Ping.

In: Molecules, Vol. 16, No. 3, 01.03.2011, p. 2274-2284.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

AU - Hsieh, Cheng Chih

AU - Lee, Hsueh Yun

AU - Nien, Chih Ying

AU - Kuo, Ching Chuan

AU - Chang, Chi Yen

AU - Chang, Jang-Yang

AU - Liou, Jing Ping

PY - 2011/3/1

Y1 - 2011/3/1

N2 - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

AB - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

UR - http://www.scopus.com/inward/record.url?scp=79953115506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953115506&partnerID=8YFLogxK

U2 - 10.3390/molecules16032274

DO - 10.3390/molecules16032274

M3 - Article

VL - 16

SP - 2274

EP - 2284

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 3

ER -