Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh; Hsueh Yun Lee; Chih Ying Nien; Ching Chuan Kuo; Chi Yen Chang; Jang Yang Chang; Jing Ping Liou

doi:10.3390/molecules16032274

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh, Hsueh Yun Lee, Chih Ying Nien, Ching Chuan Kuo, Chi Yen Chang, Jang Yang Chang, Jing Ping Liou

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

Original language	English
Pages (from-to)	2274-2284
Number of pages	11
Journal	Molecules
Volume	16
Issue number	3
DOIs	https://doi.org/10.3390/molecules16032274
Publication status	Published - 2011 Mar

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents",

abstract = "A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.",

author = "Hsieh, {Cheng Chih} and Lee, {Hsueh Yun} and Nien, {Chih Ying} and Kuo, {Ching Chuan} and Chang, {Chi Yen} and Chang, {Jang Yang} and Liou, {Jing Ping}",

year = "2011",

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doi = "10.3390/molecules16032274",

language = "English",

volume = "16",

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T1 - Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

AU - Hsieh, Cheng Chih

AU - Lee, Hsueh Yun

AU - Nien, Chih Ying

AU - Kuo, Ching Chuan

AU - Chang, Chi Yen

AU - Chang, Jang Yang

AU - Liou, Jing Ping

PY - 2011/3

Y1 - 2011/3

N2 - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

AB - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

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Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Abstract

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