Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Jang Yang Chang, Mei Jung Lai, Yi Ting Chang, Hsueh Yun Lee, Yun Ching Cheng, Ching Chuan Kuo, Min Chieh Su, Chi Yen Chang, Jing Ping Liou

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A series of 7-arylindoline-1-benzenesulfonamides were prepared and evaluated for anticancer activity. 7-(4′-Cyanophenyl)indoline-1- benzenesulfonamide 15 exhibited substantial antiproliferative activity with IC50 values ranging from 17-32 nM against a variety of human cancer cell lines, including MDR resistant line. Compound 15 (IC50 = 1.5 μM) also showed more potent inhibition of tubulin polymerization than 4a (combretastatin A-4, IC50 = 2.0 μM) and displayed strong binding to the colchicine binding site of the tubulin.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalMedChemComm
Volume1
Issue number2
DOIs
Publication statusPublished - 2010 Aug 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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