Synthesis and characterization of 3-arylidenechroman-4-ones and their inhibitory effects on platelet aggregation activity

Mopur Vijaya Bhaskar Reddy, Ping Chung Kuo, Hsin Yi Hung, Wei Jern Tsai, Tian Shung Wu

Research output: Contribution to journalArticle

Abstract

A series of 3-arylidenechroman-4-one derivatives (1-16) have been synthesized in good yields from chroman-4-one and different substituted aldehydes by the Claisen-Schmidt condensation. All the synthesized compounds were characterized by using spectroscopic analyses including IR, 1H NMR, 13C NMR, EIMS and HREIMS. The synthesized compounds were screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by adenosine diphosphate (20 μM) and collagen (10 μg/mL). Compounds 1 (81.3%), 11 (88.7%), and 13 (85.0 %) were showed potent inhibitory effects on ADP-induced aggregation activity, in which their structures possessed 2-thiophene, 3,5-dimethoxybenzene and 2,3-dimethoxybenzene moieties in the B-ring, respectively.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalDer Pharmacia Lettre
Volume8
Issue number20
Publication statusPublished - 2016 Jan 1

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Platelet Aggregation
Adenosine Diphosphate
Chromans
Thiophenes
Aldehydes
Collagen
Blood Platelets
Rabbits
In Vitro Techniques
Carbon-13 Magnetic Resonance Spectroscopy
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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title = "Synthesis and characterization of 3-arylidenechroman-4-ones and their inhibitory effects on platelet aggregation activity",
abstract = "A series of 3-arylidenechroman-4-one derivatives (1-16) have been synthesized in good yields from chroman-4-one and different substituted aldehydes by the Claisen-Schmidt condensation. All the synthesized compounds were characterized by using spectroscopic analyses including IR, 1H NMR, 13C NMR, EIMS and HREIMS. The synthesized compounds were screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by adenosine diphosphate (20 μM) and collagen (10 μg/mL). Compounds 1 (81.3{\%}), 11 (88.7{\%}), and 13 (85.0 {\%}) were showed potent inhibitory effects on ADP-induced aggregation activity, in which their structures possessed 2-thiophene, 3,5-dimethoxybenzene and 2,3-dimethoxybenzene moieties in the B-ring, respectively.",
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Synthesis and characterization of 3-arylidenechroman-4-ones and their inhibitory effects on platelet aggregation activity. / Reddy, Mopur Vijaya Bhaskar; Kuo, Ping Chung; Hung, Hsin Yi; Tsai, Wei Jern; Wu, Tian Shung.

In: Der Pharmacia Lettre, Vol. 8, No. 20, 01.01.2016, p. 14-20.

Research output: Contribution to journalArticle

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