Synthesis and characterization of self-assembled block copolymer templated calcium phosphate nanocomposite gels

D. Enlow, A. Rawal, M. Kanapathipillai, K. Schmidt-Rohr, S. Mallapragada, Chieh-Tsung Lo, P. Thiyagarajan, M. Akinc

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Self-assembled macroscale calcium phosphate-copolymer nanocomposite gels were prepared using a bottom-up approach from aqueous solutions. Amphiphilic block copolymer micelles in aqueous solutions were used as templates for the growth of calcium phosphate nanocrystals and then allowed to self-assemble in solution to form thermoreversible nanocomposite gels. NMR and XRD showed that calcium phosphate precipitation in a Pluronic® F127 copolymer gel resulted in a disordered brushite phase while the calcium phosphate-poly(2- diethylaminoethyl methacrylate) (PDEAEM) modified Pluronic® F127 pentablock copolymer nanocomposite contained the same brushite phase along with a calcium dihydrogen phosphate second phase. TEM, SAXS, and NMR experiments confirmed that the calcium phosphate precipitated on and interacted with the polymer micelles forming an organized network of ∼20 nm diameter nanospheres. The resulting polymer-calcium phosphate nanocomposite gels contained between 6.5 and 15 weight percent calcium phosphate, which could be controlled by manipulating the pH of the constituent solutions.

Original languageEnglish
Pages (from-to)1570-1578
Number of pages9
JournalJournal of Materials Chemistry
Volume17
Issue number16
DOIs
Publication statusPublished - 2007 Apr 18

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

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