Poly(N4‐1‐phenylethyl‐L‐asparagines) (1a, 1b, and 1c) containing DL‐, (R)‐, and (S)‐ side group chirality were prepared by aminolysis of poly(β‐methyl‐L‐aspartate) (PMLA) with DL‐, (R)‐ (+)‐, and (S)‐ (−)‐1‐phenylethylamine, respectively. The PMLA was synthesized by ring‐opening polymerization of β‐methyl‐L‐aspartate‐N‐carboxy anhydride (NCA) using triethylamine as initiator. The conformations of these polypeptides in the film state were investigated by IR and circular dichroic spectra. The PMLA, 1a, and 1b exist mainly in β‐sheet conformation, while 1c forms α‐helix that is induced by the (S)‐chirality of the side groups. © 1993 John Wiley & Sons, Inc.
All Science Journal Classification (ASJC) codes
- Surfaces, Coatings and Films
- Polymers and Plastics
- Materials Chemistry