Synthesis and cytotoxicity of acetyl-4H, 9H-naphtho[2,3-b]thiophene- 4,9-diones

Li Jiau Huang, Sheng Chu Kuo, Cherng Yih Perng, Yu Hua Chao, Tian Shung Wu, Andrew T. McPhail, Anthony Mauger, Huey Hwa Cheng, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Several new acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones were synthesized and evaluated for in vitro cytotoxicity by NCI against seven cancer cell types. 2,7-Diacetyl naphtho[2,3-b]thiophene-4,9-dione (9) showed significant cytotoxicity against leukemia cells with log GI50 values of - 7.61 against SR cells and - 7.18 against MOLT-4 cells. 3-Acetyl-naphtho[2,3- b]thiophene-4,9-dione (6) also demonstrated potent cytotoxicity in the latter cell line with log GI50 < -8.

Original languageEnglish
Pages (from-to)2763-2768
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 1998 Oct 6

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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