Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids

Hsing Pang Hsieh; James G. Muller; Cynthia J. Burrows

doi:10.1016/0968-0896(95)00060-T

Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids

Hsing Pang Hsieh
, James G. Muller
, Cynthia J. Burrows

Center of Applied Nanomedicine

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Seven new amino- and guanidino-substituted steroids have been synthesized from bile acid precursors, either deoxycholic acid or lithocholic acid. Their DNA binding properties have been examined using an ethidium displacement assay, through studies of hyperchromicity and thermal denaturation, and by circular dichroism. Comparison is made to simple aliphatic polyamines such as putrescine, 1,12-diaminododecane, spermidine, and spermine.

Original language	English
Pages (from-to)	823-838
Number of pages	16
Journal	Bioorganic and Medicinal Chemistry
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/0968-0896(95)00060-T
Publication status	Published - 1995 Jun

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0968-0896(95)00060-T

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Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids

Abstract

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