TY - JOUR
T1 - Synthesis and hydrogelation of star-shaped poly(L-lysine) polypeptides modified with different functional groups
AU - Shen, Xuan You
AU - Tang, Chen Chi
AU - Jan, Jeng Shiung
N1 - Funding Information:
The authors acknowledge the financial support from the Ministry of Science and Technology, Taiwan ( MOST 105-2221-E-006-248 and 106-2221-E-006-206 ). The authors acknowledge S.S.-S. Wang for access to circular dichroism. This work was financially supported by the Hierarchical Green-Energy Materials (Hi-GEM) Research Center, from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan.
Funding Information:
The authors acknowledge the financial support from the Ministry of Science and Technology, Taiwan (MOST 105-2221-E-006-248 and 106-2221-E-006-206). The authors acknowledge S.S.-S. Wang for access to circular dichroism. This work was financially supported by the Hierarchical Green-Energy Materials (Hi-GEM) Research Center, from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/8/29
Y1 - 2018/8/29
N2 - We report the synthesis and hydrogelation of star-shaped poly(L-lysine) modified with indole or phenyl group (s-PLL-g-Indo or s-PLL-g-Phenyl). The star-shaped graft copolypeptides were synthesized using readily available alcohols as the initiators to perform ring-opening polymerization (ROP) promoted by 1,1,3,3-tetramethylguanidine (TMG), followed by deprotection and side chain modification. The introduction of non-covalent interactions including hydrophobic and hydrogen bonding interactions by side chain modification promoted the spontaneous hydrogelation of these star-shaped graft copolypeptides and the gelation concentration can be as low as 0.75 wt% upon increasing the polypeptide arm number and arm length. The gel mechanical properties and molecular structures were found to dependent on the polypeptide arm number, arm length, and grafting moiety. The versatility of the star-shaped architecture allows for direct modification of the side chain, which can be an additional approach to modulate the gel mechanical properties to meet the requirement for specific applications.
AB - We report the synthesis and hydrogelation of star-shaped poly(L-lysine) modified with indole or phenyl group (s-PLL-g-Indo or s-PLL-g-Phenyl). The star-shaped graft copolypeptides were synthesized using readily available alcohols as the initiators to perform ring-opening polymerization (ROP) promoted by 1,1,3,3-tetramethylguanidine (TMG), followed by deprotection and side chain modification. The introduction of non-covalent interactions including hydrophobic and hydrogen bonding interactions by side chain modification promoted the spontaneous hydrogelation of these star-shaped graft copolypeptides and the gelation concentration can be as low as 0.75 wt% upon increasing the polypeptide arm number and arm length. The gel mechanical properties and molecular structures were found to dependent on the polypeptide arm number, arm length, and grafting moiety. The versatility of the star-shaped architecture allows for direct modification of the side chain, which can be an additional approach to modulate the gel mechanical properties to meet the requirement for specific applications.
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U2 - 10.1016/j.polymer.2018.07.051
DO - 10.1016/j.polymer.2018.07.051
M3 - Article
AN - SCOPUS:85053057425
SN - 0032-3861
VL - 151
SP - 108
EP - 116
JO - polymer
JF - polymer
ER -