Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

Ping Chung Kuo; Yue Chiun Li; Tsong Long Hwang; Guo Hao Ma; Mei Lin Yang; E. Jian Lee; Tian Shung Wu

doi:10.1016/j.tetlet.2013.10.126

Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

Ping Chung Kuo, Yue Chiun Li, Tsong Long Hwang, Guo Hao Ma, Mei Lin Yang, E. Jian Lee, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.

Original language	English
Pages (from-to)	108-110
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/j.tetlet.2013.10.126
Publication status	Published - 2014 Jan 1

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2013.10.126

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title = "Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata",

abstract = "Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.",

author = "Kuo, {Ping Chung} and Li, {Yue Chiun} and Hwang, {Tsong Long} and Ma, {Guo Hao} and Yang, {Mei Lin} and Lee, {E. Jian} and Wu, {Tian Shung}",

note = "Funding Information: Authors are grateful for the financial support of this research from the National Science Council, Taiwan, ROC . ",

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T1 - Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

AU - Kuo, Ping Chung

AU - Li, Yue Chiun

AU - Hwang, Tsong Long

AU - Ma, Guo Hao

AU - Yang, Mei Lin

AU - Lee, E. Jian

AU - Wu, Tian Shung

N1 - Funding Information: Authors are grateful for the financial support of this research from the National Science Council, Taiwan, ROC .

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.

AB - Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

Abstract

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