Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

Ping Chung Kuo, Yue Chiun Li, Tsong Long Hwang, Guo Hao Ma, Mei Lin Yang, E. Jian Lee, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata'. Together they form a unique fingerprint.

Cite this