Synthesis High Sensivity ZnO Cholesterol Biosensor with One Dimensional Nanostructures

Y. M. Lu, P. G. Jhuang, J. F. Tang, Sheng-Yuan Chu, Cw Hsu

Research output: Contribution to journalConference article

Abstract

Chelosterol ZnO biosensors were synthesized by hydrothermal method with predeposited ALD-ZnO seed layers. The ZnO nanostructures were examined by SEM, XRD, AFM, respectively. The XRD is used to analyze the crystal structures of ZnO seed layers that were grown by ALD process, then using SEM and AFM to analysis the surface morphologies of them. Growing of one dimensional ZnO nanostructures on seed layer of 10nm thickness, reveals high sensitivity of 3.15 uA (mg/dl)-1cm-2(121.96 uAmM-1cm-2) and low Km value of 29mM in 25-100mg/dl cholesterol concentration range. The response time could be as low as 10seconds. In the study, it is found that increasing the aspect ratio of ZnO one dimensional nanostructure also increases the sensitivity and expends the linear measureable range of detecting cholesterol in solution. The thickness of seed layer has a significant influence on sensitivity for one dimensional nano ZnO cholesterol biosensor.

Original languageEnglish
Article number012004
JournalIOP Conference Series: Materials Science and Engineering
Volume131
Issue number1
DOIs
Publication statusPublished - 2016 Jun 6
Event4th International Conference on Manufacturing, Optimization, Industrial and Material Engineering, MOIME 2016 - Bali, Indonesia
Duration: 2016 Mar 192016 Mar 20

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Cholesterol
Biosensors
Seed
Nanostructures
Scanning electron microscopy
Surface morphology
Aspect ratio
Crystal structure

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)

Cite this

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title = "Synthesis High Sensivity ZnO Cholesterol Biosensor with One Dimensional Nanostructures",
abstract = "Chelosterol ZnO biosensors were synthesized by hydrothermal method with predeposited ALD-ZnO seed layers. The ZnO nanostructures were examined by SEM, XRD, AFM, respectively. The XRD is used to analyze the crystal structures of ZnO seed layers that were grown by ALD process, then using SEM and AFM to analysis the surface morphologies of them. Growing of one dimensional ZnO nanostructures on seed layer of 10nm thickness, reveals high sensitivity of 3.15 uA (mg/dl)-1cm-2(121.96 uAmM-1cm-2) and low Km value of 29mM in 25-100mg/dl cholesterol concentration range. The response time could be as low as 10seconds. In the study, it is found that increasing the aspect ratio of ZnO one dimensional nanostructure also increases the sensitivity and expends the linear measureable range of detecting cholesterol in solution. The thickness of seed layer has a significant influence on sensitivity for one dimensional nano ZnO cholesterol biosensor.",
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Synthesis High Sensivity ZnO Cholesterol Biosensor with One Dimensional Nanostructures. / Lu, Y. M.; Jhuang, P. G.; Tang, J. F.; Chu, Sheng-Yuan; Hsu, Cw.

In: IOP Conference Series: Materials Science and Engineering, Vol. 131, No. 1, 012004, 06.06.2016.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Synthesis High Sensivity ZnO Cholesterol Biosensor with One Dimensional Nanostructures

AU - Lu, Y. M.

AU - Jhuang, P. G.

AU - Tang, J. F.

AU - Chu, Sheng-Yuan

AU - Hsu, Cw

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Y1 - 2016/6/6

N2 - Chelosterol ZnO biosensors were synthesized by hydrothermal method with predeposited ALD-ZnO seed layers. The ZnO nanostructures were examined by SEM, XRD, AFM, respectively. The XRD is used to analyze the crystal structures of ZnO seed layers that were grown by ALD process, then using SEM and AFM to analysis the surface morphologies of them. Growing of one dimensional ZnO nanostructures on seed layer of 10nm thickness, reveals high sensitivity of 3.15 uA (mg/dl)-1cm-2(121.96 uAmM-1cm-2) and low Km value of 29mM in 25-100mg/dl cholesterol concentration range. The response time could be as low as 10seconds. In the study, it is found that increasing the aspect ratio of ZnO one dimensional nanostructure also increases the sensitivity and expends the linear measureable range of detecting cholesterol in solution. The thickness of seed layer has a significant influence on sensitivity for one dimensional nano ZnO cholesterol biosensor.

AB - Chelosterol ZnO biosensors were synthesized by hydrothermal method with predeposited ALD-ZnO seed layers. The ZnO nanostructures were examined by SEM, XRD, AFM, respectively. The XRD is used to analyze the crystal structures of ZnO seed layers that were grown by ALD process, then using SEM and AFM to analysis the surface morphologies of them. Growing of one dimensional ZnO nanostructures on seed layer of 10nm thickness, reveals high sensitivity of 3.15 uA (mg/dl)-1cm-2(121.96 uAmM-1cm-2) and low Km value of 29mM in 25-100mg/dl cholesterol concentration range. The response time could be as low as 10seconds. In the study, it is found that increasing the aspect ratio of ZnO one dimensional nanostructure also increases the sensitivity and expends the linear measureable range of detecting cholesterol in solution. The thickness of seed layer has a significant influence on sensitivity for one dimensional nano ZnO cholesterol biosensor.

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