Synthesis of 1-(2-Carboxyethylbenzyl)-2-benzenesulfonamidobicyclo[2.2.1]heptane

A Novel Potent Thromboxane Antagonist

Wai-Ming Kan, Ching Yuh Chern, Sheng Fang Su

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A potent thromboxane antagonist, 1-[2-(2-carboxyethyl)benzyl)]-2-benzenesulfonamidobicyclo-[2.2.1]heptane was synthesized from norcamphor in 8 steps. It was shown to be a very potent thromboxane antagonist by inhibition of platelet aggregation induced by U46,619 at nanomolar concentration. The key intermediate 3-[2-bromomethylphenyl]propyl tetrahydropyran ether may be useful for the synthesis of other interphenylene containing prostaglandin analogs.

Original languageEnglish
Pages (from-to)711-712
Number of pages2
JournalJournal of the Chinese Chemical Society
Volume45
Issue number6
DOIs
Publication statusPublished - 1998 Jan 1

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Heptanes
Thromboxanes
Synthetic Prostaglandins
Platelets
Ether
Agglomeration
norcamphor

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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abstract = "A potent thromboxane antagonist, 1-[2-(2-carboxyethyl)benzyl)]-2-benzenesulfonamidobicyclo-[2.2.1]heptane was synthesized from norcamphor in 8 steps. It was shown to be a very potent thromboxane antagonist by inhibition of platelet aggregation induced by U46,619 at nanomolar concentration. The key intermediate 3-[2-bromomethylphenyl]propyl tetrahydropyran ether may be useful for the synthesis of other interphenylene containing prostaglandin analogs.",
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Synthesis of 1-(2-Carboxyethylbenzyl)-2-benzenesulfonamidobicyclo[2.2.1]heptane : A Novel Potent Thromboxane Antagonist. / Kan, Wai-Ming; Chern, Ching Yuh; Su, Sheng Fang.

In: Journal of the Chinese Chemical Society, Vol. 45, No. 6, 01.01.1998, p. 711-712.

Research output: Contribution to journalArticle

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