Synthesis of 5-arylamino-1-arylpyrazoles from 5-aminopyrazoles with arylhalides via CuI catalyzed Ullman coupling reaction

En Chiuan Chang, Chun Yen Chen, Li Ya Wang, Yu Ying Huang, Mou Yung Yeh, Fung Fuh Wong

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

An efficient method for synthesis of 5-arylamino-1-arylpyrazoles was developed by Ullman coupling reaction of 5-aminopyrazoles and arylhalides in the presence of cuprous iodide (CuI) as the catalyst. The corresponding 5-N-arylaminopyrazole products were obtained in good yields (≥65%).

Original languageEnglish
Pages (from-to)570-576
Number of pages7
JournalTetrahedron
Volume69
Issue number2
DOIs
Publication statusPublished - 2013 Jan 14
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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