Synthesis of analogues of gingerol and shogaol, the active pungent principles from the rhizomes of Zingiber officinale and evaluation of their anti-platelet aggregation effects

Hung Cheng Shih, Ching Yuh Chern, Ping Chung Kuo, You Cheng Wu, Yu Yi Chan, Yu Ren Liao, Che Ming Teng, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. Among the tested compounds, [6]-paradol (5b) exhibited the most significant anti-platelet aggregation activity. It was the most potent candidate, which could be used in further investigation to explore new drug leads.

Original languageEnglish
Pages (from-to)3926-3951
Number of pages26
JournalInternational journal of molecular sciences
Volume15
Issue number3
DOIs
Publication statusPublished - 2014 Mar 4

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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