Synthesis of (E)-5-methoxy-2-styryl-4-pyrones as potent growth-inhibitory agents against hepatocellular carcinoma cells

Yu Hua Chen, Pei-Jung Lu, Christopher Hulme, Arthur Y. Shaw

Research output: Contribution to journalArticle

Abstract

The present study a series of (E)-5-methoxy-2-styryl-4H-pyran-4-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. The growth inhibition study of eight carcinoma cell lines was examined and demonstrated that SKHep cells exhibit significant structure-activity relationship in response to the tested compounds. Among them, 6f showed the most potent activity against SKHep, A549, AGS, and H460 cell lines with GI50 values of 0.17, 8.3, 3.6, 8.0 μM, respectively.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume51
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Pyrones
Cells
Pyrans

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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Synthesis of (E)-5-methoxy-2-styryl-4-pyrones as potent growth-inhibitory agents against hepatocellular carcinoma cells. / Chen, Yu Hua; Lu, Pei-Jung; Hulme, Christopher; Shaw, Arthur Y.

In: Journal of Heterocyclic Chemistry, Vol. 51, No. 1, 01.01.2014, p. 56-61.

Research output: Contribution to journalArticle

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AB - The present study a series of (E)-5-methoxy-2-styryl-4H-pyran-4-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. The growth inhibition study of eight carcinoma cell lines was examined and demonstrated that SKHep cells exhibit significant structure-activity relationship in response to the tested compounds. Among them, 6f showed the most potent activity against SKHep, A549, AGS, and H460 cell lines with GI50 values of 0.17, 8.3, 3.6, 8.0 μM, respectively.

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