Synthesis of gingerdione derivatives as potent antiplatelet agents

Ya Yun Lai, Li Jiau Huang, Hsien Cheng Lin, Tian-Shung Wu, Che Ming Teng, Sheng Chu Kuo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In search of novel antiplatelet agents, the naturally-occurring gingerdiones (20, 24) were selected as lead compounds. A series of their derivatives were synthesized and screened for antiplatelet activity. It was found that all of the synthesized gingerdione derivatives demonstrated potent inhibition against AA-induced platelet aggregation. Among them, [4]-gingerdione (18) and [5]-gingerdione (19) showed the highest potency, being about 1/3 and one time as potent as indomethacin, respectively. Preliminary studies indicated that the mechanism of action of these gingerdione derivatives differed from indomethacin. Unlike indomethacin, they showed no appreciable COX-1 and COX-2 inhibition. The exact mechanism of action of these new compounds should be further investigated.

Original languageEnglish
Pages (from-to)259-269
Number of pages11
JournalChinese Pharmaceutical Journal
Volume54
Issue number4
Publication statusPublished - 2002 Aug 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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  • Cite this

    Lai, Y. Y., Huang, L. J., Lin, H. C., Wu, T-S., Teng, C. M., & Kuo, S. C. (2002). Synthesis of gingerdione derivatives as potent antiplatelet agents. Chinese Pharmaceutical Journal, 54(4), 259-269.