Synthesis of glyfoline, a constituent of glycosmis citrifolia (Willd.) Lindl. and a potential anticancer agent

Tsann Long Su, Krzysztof Dziewiszek, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Condensation of 4-benzyloxy-3-methoxyanthranilic acid (3) with 5-iodo-1,2,3,4-tetramethoxybenzene (4) gave 6-benzyloxy-1,2,3,4,5-pentamethoxy-9-acridone (5), which was then converted into glyfoline (1) via N-methylation, selective de-O-methylation, and debenzylation. The synthetic glyfoline (1) is identical with an authentic sample isolated from plant.

Original languageEnglish
Pages (from-to)1541-1544
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number12
DOIs
Publication statusPublished - 1991 Mar 18

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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