TY - JOUR
T1 - Synthesis of glyfoline, a constituent of glycosmis citrifolia (Willd.) Lindl. and a potential anticancer agent
AU - Su, Tsann Long
AU - Dziewiszek, Krzysztof
AU - Wu, Tian Shung
N1 - Funding Information:
This investigation was supported in part by funds from the National Cancer Institute, National Institute of Health, USD?UiS, Grants no: CA-18856 and CA-08748. We would like to thank Dr. Kyoichi A. Watanabe, Head of the Laboratory of Organic Chemistry of this Institute for his warm interest and many helpful discussions and suggestions on various aspects of this research.
PY - 1991/3/18
Y1 - 1991/3/18
N2 - Condensation of 4-benzyloxy-3-methoxyanthranilic acid (3) with 5-iodo-1,2,3,4-tetramethoxybenzene (4) gave 6-benzyloxy-1,2,3,4,5-pentamethoxy-9-acridone (5), which was then converted into glyfoline (1) via N-methylation, selective de-O-methylation, and debenzylation. The synthetic glyfoline (1) is identical with an authentic sample isolated from plant.
AB - Condensation of 4-benzyloxy-3-methoxyanthranilic acid (3) with 5-iodo-1,2,3,4-tetramethoxybenzene (4) gave 6-benzyloxy-1,2,3,4,5-pentamethoxy-9-acridone (5), which was then converted into glyfoline (1) via N-methylation, selective de-O-methylation, and debenzylation. The synthetic glyfoline (1) is identical with an authentic sample isolated from plant.
UR - https://www.scopus.com/pages/publications/0026058445
UR - https://www.scopus.com/pages/publications/0026058445#tab=citedBy
U2 - 10.1016/S0040-4039(00)74267-5
DO - 10.1016/S0040-4039(00)74267-5
M3 - Article
AN - SCOPUS:0026058445
SN - 0040-4039
VL - 32
SP - 1541
EP - 1544
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 12
ER -