Synthesis of porous TiO2/SiO2 monodisperse hollow spheres as a platform for phosphopeptide enrichment

Po Tsun Shen; Chao Hui Liu; Shih Shin Liang; Hong Ping Lin; Chun-Han Hsu

doi:10.1007/s10934-024-01564-1

Synthesis of porous TiO₂/SiO₂ monodisperse hollow spheres as a platform for phosphopeptide enrichment

Po Tsun Shen, Chao Hui Liu, Shih Shin Liang, Hong Ping Lin, Chun-Han Hsu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

A uniform dispersion of TiO₂/SiO₂ hollow nanosphere of 290 nm with a high surface area of more than 100 m²g^{− 1} is prepared using polystyrene spheres as templates after calcination at 600 °C. The TiO₂/SiO₂ hollow nanospheres are characterized by scanning electron microscopy, transmission electron microscopy, dynamic light scattering, nitrogen adsorption-desorption isotherms, and X-ray diffraction. The TiO₂/SiO₂ hollow nanospheres are shown to be highly effective in selectively enriching phosphopeptides, resulting in a significant reduction of non-phosphorylated species and an enhanced presence of modified peptides. The favorable results obtained in the present study for the enrichment of phosphoprotein β-casein pave the way toward a similar treatment of other types of biomolecules.

Original language	English
Pages (from-to)	877-886
Number of pages	10
Journal	Journal of Porous Materials
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s10934-024-01564-1
Publication status	Published - 2024 Jun

All Science Journal Classification (ASJC) codes

General Materials Science
Mechanics of Materials
Mechanical Engineering

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title = "Synthesis of porous TiO2/SiO2 monodisperse hollow spheres as a platform for phosphopeptide enrichment",

abstract = "A uniform dispersion of TiO2/SiO2 hollow nanosphere of 290 nm with a high surface area of more than 100 m2g− 1 is prepared using polystyrene spheres as templates after calcination at 600 °C. The TiO2/SiO2 hollow nanospheres are characterized by scanning electron microscopy, transmission electron microscopy, dynamic light scattering, nitrogen adsorption-desorption isotherms, and X-ray diffraction. The TiO2/SiO2 hollow nanospheres are shown to be highly effective in selectively enriching phosphopeptides, resulting in a significant reduction of non-phosphorylated species and an enhanced presence of modified peptides. The favorable results obtained in the present study for the enrichment of phosphoprotein β-casein pave the way toward a similar treatment of other types of biomolecules.",

author = "Shen, {Po Tsun} and Liu, {Chao Hui} and Liang, {Shih Shin} and Lin, {Hong Ping} and Chun-Han Hsu",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.",

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doi = "10.1007/s10934-024-01564-1",

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T1 - Synthesis of porous TiO2/SiO2 monodisperse hollow spheres as a platform for phosphopeptide enrichment

AU - Shen, Po Tsun

AU - Liu, Chao Hui

AU - Liang, Shih Shin

AU - Lin, Hong Ping

AU - Hsu, Chun-Han

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

PY - 2024/6

Y1 - 2024/6

N2 - A uniform dispersion of TiO2/SiO2 hollow nanosphere of 290 nm with a high surface area of more than 100 m2g− 1 is prepared using polystyrene spheres as templates after calcination at 600 °C. The TiO2/SiO2 hollow nanospheres are characterized by scanning electron microscopy, transmission electron microscopy, dynamic light scattering, nitrogen adsorption-desorption isotherms, and X-ray diffraction. The TiO2/SiO2 hollow nanospheres are shown to be highly effective in selectively enriching phosphopeptides, resulting in a significant reduction of non-phosphorylated species and an enhanced presence of modified peptides. The favorable results obtained in the present study for the enrichment of phosphoprotein β-casein pave the way toward a similar treatment of other types of biomolecules.

AB - A uniform dispersion of TiO2/SiO2 hollow nanosphere of 290 nm with a high surface area of more than 100 m2g− 1 is prepared using polystyrene spheres as templates after calcination at 600 °C. The TiO2/SiO2 hollow nanospheres are characterized by scanning electron microscopy, transmission electron microscopy, dynamic light scattering, nitrogen adsorption-desorption isotherms, and X-ray diffraction. The TiO2/SiO2 hollow nanospheres are shown to be highly effective in selectively enriching phosphopeptides, resulting in a significant reduction of non-phosphorylated species and an enhanced presence of modified peptides. The favorable results obtained in the present study for the enrichment of phosphoprotein β-casein pave the way toward a similar treatment of other types of biomolecules.

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JF - Journal of Porous Materials

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ER -

Synthesis of porous TiO₂/SiO₂ monodisperse hollow spheres as a platform for phosphopeptide enrichment

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