Synthesis of porous TiO2/SiO2 monodisperse hollow spheres as a platform for phosphopeptide enrichment

Po Tsun Shen, Chao Hui Liu, Shih Shin Liang, Hong Ping Lin, Chun-Han Hsu

Research output: Contribution to journalArticlepeer-review

Abstract

A uniform dispersion of TiO2/SiO2 hollow nanosphere of 290 nm with a high surface area of more than 100 m2g− 1 is prepared using polystyrene spheres as templates after calcination at 600 °C. The TiO2/SiO2 hollow nanospheres are characterized by scanning electron microscopy, transmission electron microscopy, dynamic light scattering, nitrogen adsorption-desorption isotherms, and X-ray diffraction. The TiO2/SiO2 hollow nanospheres are shown to be highly effective in selectively enriching phosphopeptides, resulting in a significant reduction of non-phosphorylated species and an enhanced presence of modified peptides. The favorable results obtained in the present study for the enrichment of phosphoprotein β-casein pave the way toward a similar treatment of other types of biomolecules.

Original languageEnglish
Pages (from-to)877-886
Number of pages10
JournalJournal of Porous Materials
Volume31
Issue number3
DOIs
Publication statusPublished - 2024 Jun

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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