Synthesis of silica/polypeptide hybrid nanomaterials and mesoporous silica by molecular replication of sheet-like polypeptide complexes through biomimetic mineralization

Kuan Ju Chen, Hsin Ling Chen, Chen Chi Tang, Hsu Heng Wu, Jeng-Shiung Jan

Research output: Contribution to journalArticle

Abstract

Biomimetic synthesis of silica/polymer hybrid nanomaterials inspired by silica-condensing microorganisms has gained significant advances in recent years and the as-prepared hybrid materials have been explored for a variety of applications. In this work, silica/polypeptide hybrid nanoparticles (NPs) and coating films can be facilely fabricated by silica mineralization of poly(L-lysine)-block-poly(L-threonine)/poly(L-glutamic acid) (PLL-b-PLT/PGA) fibril complexes assembled in solutions or on substrates at benign conditions. The experimental data revealed that PLL-b-PLT can self-assemble to form fibrils via intermolecular hydrogen bonding interactions between PLT chains and, upon complexing with PGA, silicas were efficiently mineralized in both the sheet-like PLL/PGA complexes and PLT domains, resulting in the fabrication of silica/polypeptide hybrid materials. After removing the polypeptides, mesoporous silicas exhibiting pore size between 2 and 10 nm and large pores (>10 nm) were fabricated by the replication of the sheet-like polypeptides and fibril complexes/aggregates, respectively. This study demonstrates that these polypeptide fibril complexes can serve both as nucleating agents and as templates for the fabrication of oxide/polypeptide hybrid NPs, mesoporous oxides and oxide/polypeptide coating films, which have potential applications in a variety of areas.

Original languageEnglish
Pages (from-to)243-252
Number of pages10
JournalJournal of Colloid And Interface Science
Volume542
DOIs
Publication statusPublished - 2019 Apr 15

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Polypeptides
Biomimetics
Nanostructured materials
Silicon Dioxide
Silica
Peptides
Prostaglandins A
Phase locked loops
Oxides
Hybrid materials
Nanoparticles
Fabrication
Coatings
Threonine
Microorganisms
Lysine
Pore size
Glutamic Acid
Hydrogen bonds
Polymers

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Cite this

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title = "Synthesis of silica/polypeptide hybrid nanomaterials and mesoporous silica by molecular replication of sheet-like polypeptide complexes through biomimetic mineralization",
abstract = "Biomimetic synthesis of silica/polymer hybrid nanomaterials inspired by silica-condensing microorganisms has gained significant advances in recent years and the as-prepared hybrid materials have been explored for a variety of applications. In this work, silica/polypeptide hybrid nanoparticles (NPs) and coating films can be facilely fabricated by silica mineralization of poly(L-lysine)-block-poly(L-threonine)/poly(L-glutamic acid) (PLL-b-PLT/PGA) fibril complexes assembled in solutions or on substrates at benign conditions. The experimental data revealed that PLL-b-PLT can self-assemble to form fibrils via intermolecular hydrogen bonding interactions between PLT chains and, upon complexing with PGA, silicas were efficiently mineralized in both the sheet-like PLL/PGA complexes and PLT domains, resulting in the fabrication of silica/polypeptide hybrid materials. After removing the polypeptides, mesoporous silicas exhibiting pore size between 2 and 10 nm and large pores (>10 nm) were fabricated by the replication of the sheet-like polypeptides and fibril complexes/aggregates, respectively. This study demonstrates that these polypeptide fibril complexes can serve both as nucleating agents and as templates for the fabrication of oxide/polypeptide hybrid NPs, mesoporous oxides and oxide/polypeptide coating films, which have potential applications in a variety of areas.",
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Synthesis of silica/polypeptide hybrid nanomaterials and mesoporous silica by molecular replication of sheet-like polypeptide complexes through biomimetic mineralization. / Chen, Kuan Ju; Chen, Hsin Ling; Tang, Chen Chi; Wu, Hsu Heng; Jan, Jeng-Shiung.

In: Journal of Colloid And Interface Science, Vol. 542, 15.04.2019, p. 243-252.

Research output: Contribution to journalArticle

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