Synthesis of the chiral pair of a novel thromboxane antagonist, 3-[2-(3-benzenesulfonylamino-7-oxabicyclo[2.2.1]hept-2-yl-methyl)phenyl] propionic acid

Ching Yuh Chern, Yung Lee Yek, Ja Ding Jan, Wai Ming Kan

Research output: Contribution to journalArticle

Abstract

Preparation of the enantiomeric pair of 3-[2-(3-benzenesulfonylamino-7-oxabicyclo[2.2.1]hept-2-yl-methyl)phenyl] propionic acid, a novel thromboxane antagonist is reported. They are synthesized from either enantiomers of known (1R,2R,3R,4S)-3-[2-(3-carboxy-7-oxabicyclo[2,2,1]hept-2-yl-methyl)phenyl]- propionic acid methyl ester via epimerization, modified Curtius' rearrangement and sulfonylamino formation. Other derivatives may be prepared similarly.

Original languageEnglish
Pages (from-to)907-912
Number of pages6
JournalJournal of the Chinese Chemical Society
Volume48
Issue number5
DOIs
Publication statusPublished - 2001 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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