Synthetic green fluorescent protein chromophore analogues with a positive charge at the phenyl-like group

Zhao Yi Zhang, Robert Sung, Kuangsen Sung

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Synthetic green fluorescent protein (GFP) chromophore analogues with a positive charge at the phenyl-like group have the highly electrophilic amidine carbon, smaller LUMO–HOMO energy gap, red-shifted electronic absorptions and fluorescent emissions, and accelerated E-Z thermoisomerization rates. They are water-labile and their hydrolysis results in ring-opening of the imidazolinone moiety with a half life around 25–37 h in D2O at 25 °C.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalAmino Acids
Volume50
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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