Abstract
Naevus sebaceus has recently been shown to result from post-zygotic mutations in HRAS, KRAS or occasionally NRAS. We present details of a neonate with extensive naevus sebaceus in whom we identified a pathogenic mutation in HRAS (c.37G > C; p.Gly13Arg), but only in lesional skin DNA, consistent with a mosaic RASopathy. This case highlights the clinicopathological and molecular findings of this naevoid disorder as well as the key issues in the clinical assessment and management of such patients.
Original language | English |
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Pages (from-to) | 58-60 |
Number of pages | 3 |
Journal | Australasian Journal of Dermatology |
Volume | 58 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2017 Feb 1 |
All Science Journal Classification (ASJC) codes
- Dermatology