Tailored nanoparticles for tumour therapy

Pei Shin Jiang, Philip Drake, Hui Ju Cho, Chao Hung Kao, Kun Feng Lee, Chien Hung Kuo, Xi-Zhang Lin, Yuh Jiuan Lin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gd doped iron-oxide nanoparticles were developed for use in tumour therapy via magnetic fluid hyperthermia (MFH). The effect of the Gd 3+ dopant on the particle size and magnetic properties was investigated. The final particle composition varied from Gd 001Fe 0.99O 4 to Gd 0.04Fe 2.96O 4 as determined by Inductively coupled plasma atomic emission spectroscopy (ICP-AES). TEM image analysis showed the average magnetic core diameters to be 12nm and 33nm for the lowest and highest Gd levels respectively. The specific power adsorption rate (SAR) determined with a field strength of 246 Oe and 52 kHz had a maximum of 38Wg ?1 [Fe] for the Gd 0.03Fe 2.97O 4 sample. This value is about 4 times higher than the reported SAR values for Fe 3O 4. The potential for in vivo tumour therapy was investigated using a mouse model. The mouse models treated with Gd 0.02Fe 0.98O 4 displayed much slower tumour growth after the first treatment cycle, the tumour had increased its mass by 25% after 7 days post treatment compared to a 79% mass increase over the same period for those models treated with standard iron-oxide or saline solution. After a second treatment cycle the mouse treated with Gd 0.02Fe 0.98O 1 showed complete tumour regression with no tumour found for at least 5 days post treatment.

Original languageEnglish
Pages (from-to)5076-5081
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume12
Issue number6
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Jiang, P. S., Drake, P., Cho, H. J., Kao, C. H., Lee, K. F., Kuo, C. H., Lin, X-Z., & Lin, Y. J. (2012). Tailored nanoparticles for tumour therapy. Journal of Nanoscience and Nanotechnology, 12(6), 5076-5081. https://doi.org/10.1166/jnn.2012.4890