Target-size embracing dimension for sensitive detection of viruses with various sizes and influenza virus strains

Ying Yi Lin, Jiunn Der Liao, Mei Lin Yang, Chao Liang Wu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The focused ion beam (FIB) technique was employed to precisely fabricate hexagon-like Au nano-rods (fibAu_h) arrays as a surface enhanced Raman scattering - active substrate. A " ring diameter" (D R) was created by the convergence of three fibAu_h with respect to the dimension of the target viruses (D T), such as adenovirus (Adeno), encephalomyocarditis virus (EMCV), influenza virus (H1N1) with different sizes. Three influenza A virus strains were also compared. The results indicate that as that with a D R/D T ratio of around 1, the discrimination ability for detecting the target viruses and SERS mechanism become obvious. The enhanced lightning rod effect surrounding the seized target virus is anticipated if its size and dimension is suitably embraced within three fibAu_h. Hence the as-designed fibAu_h sample with a target-size embracing dimension provides good discrimination ability for distinguishing virus of various sizes or virus strains.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalBiosensors and Bioelectronics
Volume35
Issue number1
DOIs
Publication statusPublished - 2012 May 15

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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