Targeted drug-loading microbubbles with focused ultrasound induced blood-brain barrier disruption for glioma treatment

Chien Yu Ting, Ching Hsiang Fan, Hao Li Liu, Tzu Chen Yen, Kuo Chen Wei, Chih Kuang Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Focused ultraousnd (FUS) with the presence of microbubbles (MBs) has been demonstrated its capability of temporally and locally open the blood-brain barrier (BBB) that can be utilized to enhance chemotherapeutic drug delivery into the brain parenchyma for glioma treatment. However, the current administered chemotherapeutic agents that provide tumor-killing effect also induce systemic toxicity that significantly limits the dosage. Our previous results have already demonstrated the success of concurrently applying drug (BCNU)-loaded MBs with FUS exposures to open the BBB, which provided benefits in local drug delivery and reduced systemic toxicity. To further enhance the drug targeting and releasing capability of the drug-loaded MBs, we demonstrated here a novel VEGF-targeting, drug-loaded microbubble design for the use of FUS-BBB opening and brain drug delivery. This study may provide useful implications toward future MB design which aims to perform the targeted brain tumor therapy or extend the application of microbubbles on theragnostic purpose.

Original languageEnglish
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages1862-1865
Number of pages4
DOIs
Publication statusPublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: 2012 Oct 72012 Oct 10

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period12-10-0712-10-10

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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