Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Jih Ru Hwu, Yu Sern Lin, Thainashmuthu Josephrajan, Ming Hua Hsu, Fong Yu Cheng, Chen-Sheng Yeh, Wu-Chou Su, Dar-Bin Shieh

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140 Citations (Scopus)

Abstract

The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number1
DOIs
Publication statusPublished - 2009 Jan 14

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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