Targeting ASIC3 for pain, anxiety, and insulin resistance

Wei Li Wu, Ching Feng Cheng, Wei Hsin Sun, Chia Wen Wong, Chih Cheng Chen

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The acid-sensing ion channel 3 (ASIC3) is a pH sensor that responds to mild extracellular acidification and is predominantly expressed in nociceptors. There is much interest in targeting ASIC3 to relieve pain associated with tissue acidosis, and selective drugs targeting ASIC3 have been used to relieve acid-evoked pain in animal models and human studies. There is accumulating evidence that ASIC3 is widely expressed in many neuronal and non-neuronal cells, such as neurons in the brain and adipose cells, albeit to a lesser extent than in nociceptors. Asic3-knockout mice have reduced anxiety levels and enhanced insulin sensitivity, suggesting that antagonizing ASIC3 has additional benefits. This view is tempered by recent studies suggesting that Asic3-knockout mice may experience cardiovascular disturbances. Due to the development of ASIC3 antagonists as analgesics, we review here the additional benefits, safety, risks, and strategy associated with antagonizing ASIC3 function.

Original languageEnglish
Pages (from-to)127-138
Number of pages12
JournalPharmacology and Therapeutics
Volume134
Issue number2
DOIs
Publication statusPublished - 2012 May 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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