@article{5e71637e162e41069c8c4b4cb79ac999,
title = "TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1",
abstract = "Chu et al. explore mechanisms of TDP-43-mediated dendritic mRNA transport, combining molecular approaches, real-time imaging, and an RNA biosensor. Analysis of the kinetics and dynamics of coupled transport-translation processes of Rac1 mRNA in neuronal dendrites demonstrates that TDP-43 regulates these processes in cooperation with FMRP and Staufen1 in different subcompartments.",
author = "Chu, {Jen Fei} and Pritha Majumder and Biswanath Chatterjee and Huang, {Shih Ling} and Shen, {Che Kun James}",
note = "Funding Information: We thank Yi-Shuian Huang (IBMS, Academia Sinica) for her advice during the course of this study. The expertise of Dr. Yu-Chi Chou, Dr. Ching-Wei Cheng, and other members of RNAi core, Academia Sinica facility are greatly appreciated. Kind help, whenever needed, from Sue-Ping Lee and Shu-Mei Huang in the Microscopy Core at IMB, Dr. Po-Yen Lin in the imaging core facility of ICOB, and all members of FACS facility at IMB are greatly appreciated. We sincerely convey our gratitude to Dr. John O{\textquoteright}Brien from English Editing Service, IMB, Academia Sinica for his help in editing of the manuscript. This work was supported by the Frontier of Science Award from the Ministry of Science and Technology , Taiwan (R.O.C.) and a Senior Investigator Award from the Academia Sinica , Taipei, Taiwan (R.O.C.). Funding Information: We thank Yi-Shuian Huang (IBMS, Academia Sinica) for her advice during the course of this study. The expertise of Dr. Yu-Chi Chou, Dr. Ching-Wei Cheng, and other members of RNAi core, Academia Sinica facility are greatly appreciated. Kind help, whenever needed, from Sue-Ping Lee and Shu-Mei Huang in the Microscopy Core at IMB, Dr. Po-Yen Lin in the imaging core facility of ICOB, and all members of FACS facility at IMB are greatly appreciated. We sincerely convey our gratitude to Dr. John O'Brien from English Editing Service, IMB, Academia Sinica for his help in editing of the manuscript. This work was supported by the Frontier of Science Award from the Ministry of Science and Technology, Taiwan (R.O.C.) and a Senior Investigator Award from the Academia Sinica, Taipei, Taiwan (R.O.C.). J.-F.C. P.M. and C.-K.J.S. designed the experiments. P.M. and J.-F.C. did all the imaging experiments. B.C. did the plasmid cloning and generation of genetically modified cells using CRISPR/Cas9 technology, with the help of S.-L.H. P.M. and B.C. did all the molecular biological experiments. P.M. and J.-F.C. did all data analysis. P.M. J.-F.C. and C.-K.J.S. wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = dec,
day = "3",
doi = "10.1016/j.celrep.2019.10.061",
language = "English",
volume = "29",
pages = "3118--3133.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}