Teicoplanin-induced hypersensitivity syndrome with a preceding vancomycin-induced neutropenia: A case report and literature review

S. H. Hsiao, H. H. Chen, Chen-Hsi Chou, W. L. Lin, P. Y. Liu Yeh, T. J. Wu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Hypersensitivity syndrome associated with teicoplanin has rarely been reported. We report a case with a preceding episode of vancomyin-related neutropenia. A 47-year-old female with cervical spine infection was treated with vancomycin. Neutropenia occurred after 17 days of vancomycin therapy. Vancomycin was changed to teicoplanin, and the neutropenia resolved 4 days later. After 11 days of teicoplanin therapy, a new episode of hypersensitivity syndrome manifested as fever, bilateral neck lymphadenopathy, mild wheezing, hepatitis and increased CRP occurred. Neutropenia and thrombocytopenia developed 3 days later. The patient's symptoms settled over 1 week following withdrawal of teicoplanin. Naranjo's ADR algorithm categorized the neutropenia associated with vancomycin and the hypersensitivity syndrome associated with teicoplanin as 'probable'.

Original languageEnglish
Pages (from-to)729-732
Number of pages4
JournalJournal of Clinical Pharmacy and Therapeutics
Volume35
Issue number6
DOIs
Publication statusPublished - 2010 Dec 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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