Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams: SMART program 2001 data

Po Ren Hsueh, Lee Jene Teng, Tsu Lan Wu, Dine Yang, Wen Kuei Huang, Jainn Ming Shyr, Yin Ching Chuang, Jen Hsien Wan, Jing Jou Yan, Jang Jih Lu, Jiunn Jong Wu, Wen Chien Ko, Feng Yee Chang, Yi Chueh Yang, Yeu Jun Lau, Yung Ching Liu, Chun Ming Lee, Hsieh Shong Leu, Cheng Yi Liu, Kwen Tay Luh

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Abstract

There is a high prevalence of β-lactam- and macrolide-resistant Streptococcus pneumoniae in Taiwan. To understand the in vitro susceptibilities of recent isolates of S. pneumoniae to fluoroquinolones and telithromycin (which is not available in Taiwan), the MICs of 23 antimicrobial agents for 936 clinical isolates of S. pneumoniae isolated from different parts of Taiwan from 2000 to 2001 were determined by the agar dilution method. Overall, 72% of isolates were not susceptible to penicillin (with 61% being intermediate and 11% being resistant) and 92% were resistant to erythromycin. Telithromycin MICs were ≥1 μg/ml for 16% of the isolates, and for 99% of these isolates the MICs of all macrolides tested were ≥256 μg/ml; all of these isolates had the constitutive macrolide-lincosamide-streptogramin B phenotype. Eighty-eight percent of the isolates were resistant to three or more classes of drugs. The ciprofloxacin MICs were ≥4 μg/ml for six (0.6%) isolates from five patients collected in 2000 and 2001, and the levofloxacin MICs were ≥8 μg/ml for five of these isolates. Seven isolates for which ciprofloxacin MICs were ≥4 μg/ml, including one isolate recovered in 1999, belonged to three serotypes (serotype 19F, five isolates; serotype 23A, one isolate; and serotype 23B, one isolate). The isolates from the six patients for which ciprofloxacin MICs were ≥4 μg/ml had different pulsed-field gel electrophoresis profiles and random amplified polymorphic DNA patterns, indicating that no clonal dissemination occurred over this time period. Despite the increased rate of fluoroquinolone use, the proportion of pneumococcal isolates for which ciprofloxacin MICs were elevated (≥4 μg/ml) remained low. However, the occurrence of telithromycin resistance is impressive and raises concerns for the future.

Original languageEnglish
Pages (from-to)2145-2151
Number of pages7
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number7
DOIs
Publication statusPublished - 2003 Jul 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Hsueh, P. R., Teng, L. J., Wu, T. L., Yang, D., Huang, W. K., Shyr, J. M., Chuang, Y. C., Wan, J. H., Yan, J. J., Lu, J. J., Wu, J. J., Ko, W. C., Chang, F. Y., Yang, Y. C., Lau, Y. J., Liu, Y. C., Lee, C. M., Leu, H. S., Liu, C. Y., & Luh, K. T. (2003). Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams: SMART program 2001 data. Antimicrobial agents and chemotherapy, 47(7), 2145-2151. https://doi.org/10.1128/AAC.47.7.2145-2151.2003