Coordination has been regarded as a critical factor of successful projects. Because construction projects are highly fragmented with many participants involved at different construction stages, coordination is more complicated for contractors. A coordination systems and procedure developed by simulating circulatory system could improve coordination effectiveness of construction projects due to the natural and effective physiological functions of the human body. To verify the applicability and effectiveness of the system and procedure, two tools to quantify coordination needs and supply were proposed and a case project was tested for ten months. The results showed that the more fit between coordination needs and supply, the better the task performance, meaning that the coordination system and procedure is effective. During construction the contractor can follow the coordination procedure and assign an engineer to evaluate variation of coordination needs and supply periodically or at emergent conditions. As coordination supply does not meet needs, time and frequency of coordination methods should be adjusted.