Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

Su Jane Wang, Chiung Chun Huang, Po Wu Gean

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The effect of the centrally active anticholinesterase inhibitor Terahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by α-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.

Original languageEnglish
Pages (from-to)325-327
Number of pages3
JournalBrain Research Bulletin
Volume37
Issue number3
DOIs
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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