The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes

Jinghui Luo, Sebastian K.T.S. Wärmländer, Chien-hung Yu, Kamran Muhammad, Astrid Gräslund, Jan Pieter Abrahams

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Carbon nanotubes have specific properties that make them potentially useful in biomedicine and biotechnology. However, carbon nanotubes may themselves be toxic, making it imperative to understand how carbon nanotubes interact with biomolecules such as proteins. Here, we used NMR, CD, and ThT/fluorescence spectroscopy together with AFM imaging to study pH-dependent molecular interactions between single walled carbon nanotubes (SWNTs) and the amyloid-beta (Aβ) peptide. The aggregation of the Aβ peptide, first into oligomers and later into amyloid fibrils, is considered to be the toxic mechanism behind Alzheimer's disease. We found that SWNTs direct the Aβ peptides to form a new class of β-sheet-rich yet non-amyloid fibrils.

Original languageEnglish
Pages (from-to)6720-6726
Number of pages7
JournalNanoscale
Volume6
Issue number12
DOIs
Publication statusPublished - 2014 Jun 21

Fingerprint

Carbon Nanotubes
Peptides
Carbon nanotubes
Poisons
Single-walled carbon nanotubes (SWCN)
Amyloid
Molecular interactions
Fluorescence spectroscopy
Biomolecules
Biotechnology
Oligomers
Agglomeration
Nuclear magnetic resonance
Proteins
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Luo, J., Wärmländer, S. K. T. S., Yu, C., Muhammad, K., Gräslund, A., & Pieter Abrahams, J. (2014). The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes. Nanoscale, 6(12), 6720-6726. https://doi.org/10.1039/c4nr00291a
Luo, Jinghui ; Wärmländer, Sebastian K.T.S. ; Yu, Chien-hung ; Muhammad, Kamran ; Gräslund, Astrid ; Pieter Abrahams, Jan. / The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes. In: Nanoscale. 2014 ; Vol. 6, No. 12. pp. 6720-6726.
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Luo, J, Wärmländer, SKTS, Yu, C, Muhammad, K, Gräslund, A & Pieter Abrahams, J 2014, 'The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes', Nanoscale, vol. 6, no. 12, pp. 6720-6726. https://doi.org/10.1039/c4nr00291a

The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes. / Luo, Jinghui; Wärmländer, Sebastian K.T.S.; Yu, Chien-hung; Muhammad, Kamran; Gräslund, Astrid; Pieter Abrahams, Jan.

In: Nanoscale, Vol. 6, No. 12, 21.06.2014, p. 6720-6726.

Research output: Contribution to journalArticle

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Luo J, Wärmländer SKTS, Yu C, Muhammad K, Gräslund A, Pieter Abrahams J. The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes. Nanoscale. 2014 Jun 21;6(12):6720-6726. https://doi.org/10.1039/c4nr00291a