The acne genes

Wen Chieh Chen, Chao-Chun Yang, Christos C. Zouboulis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acne is one of the most common skin diseases. Many epidemiologic studies and twin studies have provided substantial evidence about the genetic influence in the development of acne [1-5], at least in certain stages of acne such as neonatal acne, teenage acne [6], adult persistent acne, or in special forms of acne such as acne comedonica, acne inversa [7, 8], acne fulminans [9], or in acne severity [10] and therapeutic resistance [11]. Acne is very likely mediated by polygenic inheritance or multifactorial inheritance attributed to the interplay between multiple genes and the environment, especially the sex hormones. It is unknown if each candidate acne gene contributes equally or additively to the disease phenotype, or whether there exists a master gene that presides or leads the disease development. All the candidate genes may influence each other and perpetuate the disease process. The problem in many of the existing epidemiologic studies may include (1) a small sample size with single or few families examined without matched control; (2) lack of standardization in the disease definition or severity classification; (3) variability of age onset, duration, course, and psychosocial influence.

Original languageEnglish
Title of host publicationPathogenesis and Treatment of Acne and Rosacea
PublisherSpringer-Verlag Berlin Heidelberg
Pages349-354
Number of pages6
Volume9783540693758
ISBN (Electronic)9783540693758
ISBN (Print)3540693742, 9783540693741
DOIs
Publication statusPublished - 2014 Nov 1

Fingerprint

Acne Vulgaris
Genes
Multifactorial Inheritance
Epidemiologic Studies
Hidradenitis Suppurativa
Twin Studies
Gonadal Steroid Hormones
Age of Onset
Skin Diseases
Sample Size
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chen, W. C., Yang, C-C., & Zouboulis, C. C. (2014). The acne genes. In Pathogenesis and Treatment of Acne and Rosacea (Vol. 9783540693758, pp. 349-354). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-540-69375-8_47
Chen, Wen Chieh ; Yang, Chao-Chun ; Zouboulis, Christos C. / The acne genes. Pathogenesis and Treatment of Acne and Rosacea. Vol. 9783540693758 Springer-Verlag Berlin Heidelberg, 2014. pp. 349-354
@inbook{be200148877d46b1af630aad40f7da45,
title = "The acne genes",
abstract = "Acne is one of the most common skin diseases. Many epidemiologic studies and twin studies have provided substantial evidence about the genetic influence in the development of acne [1-5], at least in certain stages of acne such as neonatal acne, teenage acne [6], adult persistent acne, or in special forms of acne such as acne comedonica, acne inversa [7, 8], acne fulminans [9], or in acne severity [10] and therapeutic resistance [11]. Acne is very likely mediated by polygenic inheritance or multifactorial inheritance attributed to the interplay between multiple genes and the environment, especially the sex hormones. It is unknown if each candidate acne gene contributes equally or additively to the disease phenotype, or whether there exists a master gene that presides or leads the disease development. All the candidate genes may influence each other and perpetuate the disease process. The problem in many of the existing epidemiologic studies may include (1) a small sample size with single or few families examined without matched control; (2) lack of standardization in the disease definition or severity classification; (3) variability of age onset, duration, course, and psychosocial influence.",
author = "Chen, {Wen Chieh} and Chao-Chun Yang and Zouboulis, {Christos C.}",
year = "2014",
month = "11",
day = "1",
doi = "10.1007/978-3-540-69375-8_47",
language = "English",
isbn = "3540693742",
volume = "9783540693758",
pages = "349--354",
booktitle = "Pathogenesis and Treatment of Acne and Rosacea",
publisher = "Springer-Verlag Berlin Heidelberg",

}

Chen, WC, Yang, C-C & Zouboulis, CC 2014, The acne genes. in Pathogenesis and Treatment of Acne and Rosacea. vol. 9783540693758, Springer-Verlag Berlin Heidelberg, pp. 349-354. https://doi.org/10.1007/978-3-540-69375-8_47

The acne genes. / Chen, Wen Chieh; Yang, Chao-Chun; Zouboulis, Christos C.

Pathogenesis and Treatment of Acne and Rosacea. Vol. 9783540693758 Springer-Verlag Berlin Heidelberg, 2014. p. 349-354.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - The acne genes

AU - Chen, Wen Chieh

AU - Yang, Chao-Chun

AU - Zouboulis, Christos C.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Acne is one of the most common skin diseases. Many epidemiologic studies and twin studies have provided substantial evidence about the genetic influence in the development of acne [1-5], at least in certain stages of acne such as neonatal acne, teenage acne [6], adult persistent acne, or in special forms of acne such as acne comedonica, acne inversa [7, 8], acne fulminans [9], or in acne severity [10] and therapeutic resistance [11]. Acne is very likely mediated by polygenic inheritance or multifactorial inheritance attributed to the interplay between multiple genes and the environment, especially the sex hormones. It is unknown if each candidate acne gene contributes equally or additively to the disease phenotype, or whether there exists a master gene that presides or leads the disease development. All the candidate genes may influence each other and perpetuate the disease process. The problem in many of the existing epidemiologic studies may include (1) a small sample size with single or few families examined without matched control; (2) lack of standardization in the disease definition or severity classification; (3) variability of age onset, duration, course, and psychosocial influence.

AB - Acne is one of the most common skin diseases. Many epidemiologic studies and twin studies have provided substantial evidence about the genetic influence in the development of acne [1-5], at least in certain stages of acne such as neonatal acne, teenage acne [6], adult persistent acne, or in special forms of acne such as acne comedonica, acne inversa [7, 8], acne fulminans [9], or in acne severity [10] and therapeutic resistance [11]. Acne is very likely mediated by polygenic inheritance or multifactorial inheritance attributed to the interplay between multiple genes and the environment, especially the sex hormones. It is unknown if each candidate acne gene contributes equally or additively to the disease phenotype, or whether there exists a master gene that presides or leads the disease development. All the candidate genes may influence each other and perpetuate the disease process. The problem in many of the existing epidemiologic studies may include (1) a small sample size with single or few families examined without matched control; (2) lack of standardization in the disease definition or severity classification; (3) variability of age onset, duration, course, and psychosocial influence.

UR - http://www.scopus.com/inward/record.url?scp=84927581545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927581545&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-69375-8_47

DO - 10.1007/978-3-540-69375-8_47

M3 - Chapter

AN - SCOPUS:84927581545

SN - 3540693742

SN - 9783540693741

VL - 9783540693758

SP - 349

EP - 354

BT - Pathogenesis and Treatment of Acne and Rosacea

PB - Springer-Verlag Berlin Heidelberg

ER -

Chen WC, Yang C-C, Zouboulis CC. The acne genes. In Pathogenesis and Treatment of Acne and Rosacea. Vol. 9783540693758. Springer-Verlag Berlin Heidelberg. 2014. p. 349-354 https://doi.org/10.1007/978-3-540-69375-8_47