The aldehyde dehydrogenase 2 gene is associated with heroin dependence

Tzu Yun Wang; Sheng Yu Lee; Shiou Lan Chen; Shih Heng Chen; Chun Hsien Chu; San Yuan Huang; Nian Sheng Tzeng; Yun Hsuan Chang; Chen Lin Wang; I. Hui Lee; Tzung Lieh Yeh; Yen Kuang Yang; Ru Band Lu

doi:10.1016/j.drugalcdep.2011.06.008

The aldehyde dehydrogenase 2 gene is associated with heroin dependence

Tzu Yun Wang, Sheng Yu Lee, Shiou Lan Chen, Shih Heng Chen, Chun Hsien Chu, San Yuan Huang, Nian Sheng Tzeng, Yun Hsuan Chang, Chen Lin Wang, I. Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru Band Lu

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: Determining the influences of genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) genes, is critical for understanding addictive behavior. Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence. Methods: Heroin-dependent Han Chinese patients (250) and healthy controls (312) were recruited. ALDH2 and DRD2/ANKK1 Taq IA polymorphisms were genotyped. Results: The frequency of ALDH2*1/*2 and *2/*2 genotypes was significantly higher in heroin-dependent patients than in controls, but the frequency of DRD2 Taq IA genotypes was not significantly different. Logistic regression analysis showed no significant interaction between ALDH2 and DRD2 Taq IA genotypes in patients. Conclusions: The ALDH2 polymorphism, but not the DRD2, was associated with heroin dependence.

Original language	English
Pages (from-to)	220-224
Number of pages	5
Journal	Drug and Alcohol Dependence
Volume	120
Issue number	1-3
DOIs	https://doi.org/10.1016/j.drugalcdep.2011.06.008
Publication status	Published - 2012 Jan 1

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drugalcdep.2011.06.008

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title = "The aldehyde dehydrogenase 2 gene is associated with heroin dependence",

abstract = "Background: Determining the influences of genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) genes, is critical for understanding addictive behavior. Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence. Methods: Heroin-dependent Han Chinese patients (250) and healthy controls (312) were recruited. ALDH2 and DRD2/ANKK1 Taq IA polymorphisms were genotyped. Results: The frequency of ALDH2*1/*2 and *2/*2 genotypes was significantly higher in heroin-dependent patients than in controls, but the frequency of DRD2 Taq IA genotypes was not significantly different. Logistic regression analysis showed no significant interaction between ALDH2 and DRD2 Taq IA genotypes in patients. Conclusions: The ALDH2 polymorphism, but not the DRD2, was associated with heroin dependence.",

author = "Wang, {Tzu Yun} and Lee, {Sheng Yu} and Chen, {Shiou Lan} and Chen, {Shih Heng} and Chu, {Chun Hsien} and Huang, {San Yuan} and Tzeng, {Nian Sheng} and Chang, {Yun Hsuan} and Wang, {Chen Lin} and Lee, {I. Hui} and Yeh, {Tzung Lieh} and Yang, {Yen Kuang} and Lu, {Ru Band}",

note = "Funding Information: This study was supported in part by the Ministry of Health Grant DOH98-TD-I-111-DD004 (R.B.L.); as well as by a grant from the National Cheng Kung University Project of Promoting Academic Excellence & Developing World Class Research Centers, Taiwan, Republic of China (R.B.L.). ",

year = "2012",

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doi = "10.1016/j.drugalcdep.2011.06.008",

language = "English",

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journal = "Drug and Alcohol Dependence",

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T1 - The aldehyde dehydrogenase 2 gene is associated with heroin dependence

AU - Wang, Tzu Yun

AU - Lee, Sheng Yu

AU - Chen, Shiou Lan

AU - Chen, Shih Heng

AU - Chu, Chun Hsien

AU - Huang, San Yuan

AU - Tzeng, Nian Sheng

AU - Chang, Yun Hsuan

AU - Wang, Chen Lin

AU - Lee, I. Hui

AU - Yeh, Tzung Lieh

AU - Yang, Yen Kuang

AU - Lu, Ru Band

N1 - Funding Information: This study was supported in part by the Ministry of Health Grant DOH98-TD-I-111-DD004 (R.B.L.); as well as by a grant from the National Cheng Kung University Project of Promoting Academic Excellence & Developing World Class Research Centers, Taiwan, Republic of China (R.B.L.).

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: Determining the influences of genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) genes, is critical for understanding addictive behavior. Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence. Methods: Heroin-dependent Han Chinese patients (250) and healthy controls (312) were recruited. ALDH2 and DRD2/ANKK1 Taq IA polymorphisms were genotyped. Results: The frequency of ALDH2*1/*2 and *2/*2 genotypes was significantly higher in heroin-dependent patients than in controls, but the frequency of DRD2 Taq IA genotypes was not significantly different. Logistic regression analysis showed no significant interaction between ALDH2 and DRD2 Taq IA genotypes in patients. Conclusions: The ALDH2 polymorphism, but not the DRD2, was associated with heroin dependence.

AB - Background: Determining the influences of genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) genes, is critical for understanding addictive behavior. Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence. Methods: Heroin-dependent Han Chinese patients (250) and healthy controls (312) were recruited. ALDH2 and DRD2/ANKK1 Taq IA polymorphisms were genotyped. Results: The frequency of ALDH2*1/*2 and *2/*2 genotypes was significantly higher in heroin-dependent patients than in controls, but the frequency of DRD2 Taq IA genotypes was not significantly different. Logistic regression analysis showed no significant interaction between ALDH2 and DRD2 Taq IA genotypes in patients. Conclusions: The ALDH2 polymorphism, but not the DRD2, was associated with heroin dependence.

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The aldehyde dehydrogenase 2 gene is associated with heroin dependence

Abstract

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