The alkaloids and other constituents from the root and stem of Aristolochia elegans

Li Shian Shi, Ping Chung Kuo, Yao Lung Tsai, Amooru Gangaiah Damu, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Two new aristolactams, aristolactam E (1) and aristolactam-AIIIa-6-O- β-D-glucoside (2), three novel benzoyl benzyltetrahydroisoquinoline ether N-oxide alkaloids, aristoquinoline A (3), aristoquinoline B (4), and aristoquinoline C (5), and a new biphenyl ether, aristogin F (6), together with 62 known compounds have been isolated from the root and stem of Aristolochia elegans Mast. The structures of the new natural products were established on the basis of spectral evidence. Some of the isolated compounds were examined for their antioxidative and antityrosinase activities. Occurrence of the isoquinolones, biphenyl ethers, and benzoyl benzyltetrahydroisoquinoline ether alkaloids in the same plant indicated the definite possibility of these metabolites as biotransformation intermediates of bisbenzyltetrahydroisoquinoline alkaloids. This can be useful to solve the catabolic process of bisbenzyltetrahydroisoquinoline alkaloids.

Original languageEnglish
Pages (from-to)439-446
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number2
DOIs
Publication statusPublished - 2004 Jan 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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