The Anti-bacterial and Anti-adherent Effects of Pentraxin-3 on Porcine Kidney Epithelial PK15 Cells Against Staphylococcus aureus Infection

Bao Hong Lee, Wei Hsuan Hsu, Cheng Hui Lin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Staphylococcus aureus is a common zoonotic bacterium for disease in pigs and human and causes health problem. The aim of the study is to investigate the potential of soluble pathogenic recognition protein pentraxin-3 (PTX3) on inhibiting proliferation, adhesion, and infection of S. aureus in porcine kidney epithelial PK15 cells (PK15 cells). PTX3 suppressed the growth of S. aureus and avoided it adhering to PK15 cells. PTX3 treatment also attenuated cell apoptosis induced by S. aureus in PK15 cells. The results suggest that PTX3 is able to interfere with the bacterial pathogenesis via inhibiting the growth of S. aureus and decreasing their adhesion to cells. Hence, PTX3 may replace the use of antibiotics and develop as a novel anti-microbial agent for disease prevention in piglets.

Original languageEnglish
Pages (from-to)645-652
Number of pages8
JournalInternational Journal of Peptide Research and Therapeutics
Volume25
Issue number2
DOIs
Publication statusPublished - 2019 Jun 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Bioengineering
  • Biochemistry
  • Molecular Medicine
  • Drug Discovery

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