The antinociceptive effect of light-emitting diode irradiation on incised wounds is correlated with changes in cyclooxygenase 2 activity, prostaglandin e2, and proinflammatory cytokines

Yuan Yi Chia, Chien Cheng Liu, Guan Ming Feng, Chia Chih Alex Tseng, Kuo Chuan Hung, Chih Chieh Chen, Ping Heng Tan

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. Objectives. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α). Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only. The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05). Conclusions. LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.

Original languageEnglish
Article number4792489
JournalPain Research and Management
Volume2017
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Neurology
  • Anesthesiology and Pain Medicine

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