TY - JOUR
T1 - The antinociceptive effect of light-emitting diode irradiation on incised wounds is correlated with changes in cyclooxygenase 2 activity, prostaglandin e2, and proinflammatory cytokines
AU - Chia, Yuan Yi
AU - Liu, Chien Cheng
AU - Feng, Guan Ming
AU - Tseng, Chia Chih Alex
AU - Hung, Kuo Chuan
AU - Chen, Chih Chieh
AU - Tan, Ping Heng
N1 - Publisher Copyright:
© 2017 Yuan-Yi Chia et al.
PY - 2017
Y1 - 2017
N2 - Background. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. Objectives. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α). Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only. The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05). Conclusions. LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.
AB - Background. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined. Objectives. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α). Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy. Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only. The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05). Conclusions. LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.
UR - http://www.scopus.com/inward/record.url?scp=85018806228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018806228&partnerID=8YFLogxK
U2 - 10.1155/2017/4792489
DO - 10.1155/2017/4792489
M3 - Article
C2 - 28469528
AN - SCOPUS:85018806228
SN - 1203-6765
VL - 2017
JO - Pain Research and Management
JF - Pain Research and Management
M1 - 4792489
ER -