The application of capillary force to a cantilever as a sensor for molecular recognition

T. I. Yin; Y. Zhao; C. F. Lin; H. H. Tsai; Y. Z. Juang; S. M. Yang; G. A. Urban

doi:10.1063/1.3558730

The application of capillary force to a cantilever as a sensor for molecular recognition

T. I. Yin, Y. Zhao, C. F. Lin, H. H. Tsai, Y. Z. Juang, S. M. Yang, G. A. Urban

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

This paper reports on a sensing mechanism created by converting a change in solid-liquid interfacial tension due to molecular interactions into a change in capillary force loading for a cantilever sensor design. Compared with former cantilever sensor designs based on surface stress measurement, the proposed mechanism takes advantage of capillary force to effectively amplify the signal output of the sensor by several orders of magnitude. A complementary-metal- oxide-semiconductor-based cantilever sensor design validates the proposed sensing mechanism. Detection of Biotin-NeutrAvidin specific binding in picomolar sample concentrations was demonstrated for the application of biochemical assay.

Original language	English
Article number	104102
Journal	Applied Physics Letters
Volume	98
Issue number	10
DOIs	https://doi.org/10.1063/1.3558730
Publication status	Published - 2011 Mar 7

All Science Journal Classification (ASJC) codes

Physics and Astronomy (miscellaneous)

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10.1063/1.3558730

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title = "The application of capillary force to a cantilever as a sensor for molecular recognition",

abstract = "This paper reports on a sensing mechanism created by converting a change in solid-liquid interfacial tension due to molecular interactions into a change in capillary force loading for a cantilever sensor design. Compared with former cantilever sensor designs based on surface stress measurement, the proposed mechanism takes advantage of capillary force to effectively amplify the signal output of the sensor by several orders of magnitude. A complementary-metal- oxide-semiconductor-based cantilever sensor design validates the proposed sensing mechanism. Detection of Biotin-NeutrAvidin specific binding in picomolar sample concentrations was demonstrated for the application of biochemical assay.",

author = "Yin, {T. I.} and Y. Zhao and Lin, {C. F.} and Tsai, {H. H.} and Juang, {Y. Z.} and Yang, {S. M.} and Urban, {G. A.}",

note = "Funding Information: This work is supported by a postdoctoral research scholarship of the Alex von Humboldt Foundation, Germany. The authors thank Chun Chang, Ali Cubukcu, Raimar Rostek, Josef Horak, and Victor Vartanian for providing valuable input in preparing this manuscript.",

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AU - Yin, T. I.

AU - Zhao, Y.

AU - Lin, C. F.

AU - Tsai, H. H.

AU - Juang, Y. Z.

AU - Yang, S. M.

AU - Urban, G. A.

N1 - Funding Information: This work is supported by a postdoctoral research scholarship of the Alex von Humboldt Foundation, Germany. The authors thank Chun Chang, Ali Cubukcu, Raimar Rostek, Josef Horak, and Victor Vartanian for providing valuable input in preparing this manuscript.

PY - 2011/3/7

Y1 - 2011/3/7

N2 - This paper reports on a sensing mechanism created by converting a change in solid-liquid interfacial tension due to molecular interactions into a change in capillary force loading for a cantilever sensor design. Compared with former cantilever sensor designs based on surface stress measurement, the proposed mechanism takes advantage of capillary force to effectively amplify the signal output of the sensor by several orders of magnitude. A complementary-metal- oxide-semiconductor-based cantilever sensor design validates the proposed sensing mechanism. Detection of Biotin-NeutrAvidin specific binding in picomolar sample concentrations was demonstrated for the application of biochemical assay.

AB - This paper reports on a sensing mechanism created by converting a change in solid-liquid interfacial tension due to molecular interactions into a change in capillary force loading for a cantilever sensor design. Compared with former cantilever sensor designs based on surface stress measurement, the proposed mechanism takes advantage of capillary force to effectively amplify the signal output of the sensor by several orders of magnitude. A complementary-metal- oxide-semiconductor-based cantilever sensor design validates the proposed sensing mechanism. Detection of Biotin-NeutrAvidin specific binding in picomolar sample concentrations was demonstrated for the application of biochemical assay.

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The application of capillary force to a cantilever as a sensor for molecular recognition

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