TY - JOUR
T1 - The application of tDCS for the treatment of psychiatric diseases
AU - Kuo, Min Fang
AU - Chen, Po See
AU - Nitsche, Michael A.
N1 - Funding Information:
MAN is funded by the EC (open FET program (686764)?LUNIMOUS), and BMBF (grant 01GQ1424E - TRAINSTIM, grant 01EE1403C - GCBS. PSC is funded by Ministry of Science and Technology, R.O.C (MOST 102-2314-B-006-017-MY2).
PY - 2017/3/4
Y1 - 2017/3/4
N2 - Neuroplasticity represents the dynamic structural and functional reorganization of the central nervous system, including its connectivity, due to environmental and internal demands. It is recognized as a major physiological basis for adaption of cognition and behaviour, and, thus, of utmost importance for normal brain function. Cognitive dysfunctions are major symptoms in psychiatric disorders, which are often associated with pathological alteration of neuroplasticity. Transcranial direct current stimulation (tDCS), a recently developed non-invasive brain stimulation technique, is able to induce and modulate cortical plasticity in humans via the application of relatively weak current through the scalp of the head. It has the potential to alter pathological plasticity and restore dysfunctional cognitions in psychiatric diseases. In the last decades, its efficacy to treat psychiatric disorders has been explored increasingly. This review will give an overview of pathological alterations of plasticity in psychiatric diseases, gather clinical studies involving tDCS to ameliorate symptoms, and discuss future directions of application, with an emphasis on optimizing stimulation effects.
AB - Neuroplasticity represents the dynamic structural and functional reorganization of the central nervous system, including its connectivity, due to environmental and internal demands. It is recognized as a major physiological basis for adaption of cognition and behaviour, and, thus, of utmost importance for normal brain function. Cognitive dysfunctions are major symptoms in psychiatric disorders, which are often associated with pathological alteration of neuroplasticity. Transcranial direct current stimulation (tDCS), a recently developed non-invasive brain stimulation technique, is able to induce and modulate cortical plasticity in humans via the application of relatively weak current through the scalp of the head. It has the potential to alter pathological plasticity and restore dysfunctional cognitions in psychiatric diseases. In the last decades, its efficacy to treat psychiatric disorders has been explored increasingly. This review will give an overview of pathological alterations of plasticity in psychiatric diseases, gather clinical studies involving tDCS to ameliorate symptoms, and discuss future directions of application, with an emphasis on optimizing stimulation effects.
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U2 - 10.1080/09540261.2017.1286299
DO - 10.1080/09540261.2017.1286299
M3 - Review article
C2 - 28523976
AN - SCOPUS:85019546344
VL - 29
SP - 146
EP - 167
JO - International Review of Psychiatry
JF - International Review of Psychiatry
SN - 0954-0261
IS - 2
ER -