The association of C (-260)→T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients

Tsun Mei Lin, Chih-Hung Chen, Hua-Lin Wu, Chiou Huey Wang, Yi Ling Chen, Hock Liew Eng

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The C (-260) →T polymorphism has been reported to regulate CD14 gene expression. It has also been implicated in atherosclerotic diseases, and in addition, it could be a genetic factor responsible for interindividual differences in the susceptibility to Chlamydia pneumoniae infection. This case-control study is aimed at evaluating the association between CD14 promoter polymorphisms, frequency of persistent C pneumoniae infection, and anti-chlamydial heat shock protein 60 (cHsp60) induction in stroke patients. Persistent C pneumoniae infection was observed in 43.3% of control subjects and 53.3% of patients (P = .005). The odds ratio of persistent infection was 3.25 for the CC genotype in stroke patients (P = .018). However, the serologic positive responses to cHsp60 in people with the TT genotype were significantly lower in stroke patients (9.3% vs 38.6%; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes.

Original languageEnglish
Pages (from-to)595-601
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume130
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1

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Chlamydophila pneumoniae
Chlamydia Infections
Chaperonin 60
Stroke
Genotype
Pneumonia
Infection
Case-Control Studies
Odds Ratio
Gene Expression
Antibodies

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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abstract = "The C (-260) →T polymorphism has been reported to regulate CD14 gene expression. It has also been implicated in atherosclerotic diseases, and in addition, it could be a genetic factor responsible for interindividual differences in the susceptibility to Chlamydia pneumoniae infection. This case-control study is aimed at evaluating the association between CD14 promoter polymorphisms, frequency of persistent C pneumoniae infection, and anti-chlamydial heat shock protein 60 (cHsp60) induction in stroke patients. Persistent C pneumoniae infection was observed in 43.3{\%} of control subjects and 53.3{\%} of patients (P = .005). The odds ratio of persistent infection was 3.25 for the CC genotype in stroke patients (P = .018). However, the serologic positive responses to cHsp60 in people with the TT genotype were significantly lower in stroke patients (9.3{\%} vs 38.6{\%}; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes.",
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The association of C (-260)→T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients. / Lin, Tsun Mei; Chen, Chih-Hung; Wu, Hua-Lin; Wang, Chiou Huey; Chen, Yi Ling; Eng, Hock Liew.

In: American Journal of Clinical Pathology, Vol. 130, No. 4, 01.10.2008, p. 595-601.

Research output: Contribution to journalArticle

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