The association of C (-260)→T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients

Tsun Mei Lin, Chih Hung Chen, Hua Lin Wu, Chiou Huey Wang, Yi Ling Chen, Hock Liew Eng

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The C (-260) →T polymorphism has been reported to regulate CD14 gene expression. It has also been implicated in atherosclerotic diseases, and in addition, it could be a genetic factor responsible for interindividual differences in the susceptibility to Chlamydia pneumoniae infection. This case-control study is aimed at evaluating the association between CD14 promoter polymorphisms, frequency of persistent C pneumoniae infection, and anti-chlamydial heat shock protein 60 (cHsp60) induction in stroke patients. Persistent C pneumoniae infection was observed in 43.3% of control subjects and 53.3% of patients (P = .005). The odds ratio of persistent infection was 3.25 for the CC genotype in stroke patients (P = .018). However, the serologic positive responses to cHsp60 in people with the TT genotype were significantly lower in stroke patients (9.3% vs 38.6%; P < .001). Our findings suggest that persistent C pneumoniae infection is independently associated with stroke in CC genotypes and the lowering of cHsp60 antibody levels in TT genotypes.

Original languageEnglish
Pages (from-to)595-601
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume130
Issue number4
DOIs
Publication statusPublished - 2008 Oct

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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