The bakkenolides from the root of Petasites formosanus and their cytotoxicity

Tian Shung Wu, Mang San Kao, Pei Lin Wu, Ful Wen Lin, Li Shian Shi, Meei Jen Liou, Chia Ying Li

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Thirty-two new bakkenolides, bakkenolides-Db (1) - Dh (7), -Fa (8), -Fb (9), -I (10) - M (14), -Na (15), -Nb (16), -O (17) - T (22), -Ua (23),-Ub (24),-V (25) - X (27), -Ya (28),-Yb (29), -Za (30), -Zb (31) and -III (32), from the roots of Petasites formosanus together with thirty known compounds were isolated. The structures were characterized by spectral analysis. The locations, C-1 and/or C-9 of bakkenolide skeleton, of the substituents, such as acetoxy, isobutyroyloxy and isovaleroyloxy groups, can be determined by the chemical shifts of their signals and the H-1 and/H-9 in the 1H-NMR spectra. The cytotoxicity was also discussed.

Original languageEnglish
Pages (from-to)375-382
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume47
Issue number3
DOIs
Publication statusPublished - 1999 Mar

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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