The bakkenolides from the root of Petasites formosanus and their cytotoxicity

Tian-Shung Wu; Mang San Kao; Pei Lin Wu; Ful Wen Lin; Li Shian Shi; Meei Jen Liou; Chia Ying Li

doi:10.1248/cpb.47.375

The bakkenolides from the root of Petasites formosanus and their cytotoxicity

Tian-Shung Wu, Mang San Kao, Pei Lin Wu, Ful Wen Lin, Li Shian Shi, Meei Jen Liou, Chia Ying Li

School of Pharmacy

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45 Citations (Scopus)

Abstract

Thirty-two new bakkenolides, bakkenolides-Db (1) - Dh (7), -Fa (8), -Fb (9), -I (10) - M (14), -Na (15), -Nb (16), -O (17) - T (22), -Ua (23),-Ub (24),-V (25) - X (27), -Ya (28),-Yb (29), -Za (30), -Zb (31) and -III (32), from the roots of Petasites formosanus together with thirty known compounds were isolated. The structures were characterized by spectral analysis. The locations, C-1 and/or C-9 of bakkenolide skeleton, of the substituents, such as acetoxy, isobutyroyloxy and isovaleroyloxy groups, can be determined by the chemical shifts of their signals and the H-1 and/H-9 in the ¹H-NMR spectra. The cytotoxicity was also discussed.

Original language	English
Pages (from-to)	375-382
Number of pages	8
Journal	Chemical and Pharmaceutical Bulletin
Volume	47
Issue number	3
DOIs	https://doi.org/10.1248/cpb.47.375
Publication status	Published - 1999 Jan 1

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All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

Cite this

Wu, T-S., Kao, M. S., Wu, P. L., Lin, F. W., Shi, L. S., Liou, M. J., & Li, C. Y. (1999). The bakkenolides from the root of Petasites formosanus and their cytotoxicity. Chemical and Pharmaceutical Bulletin, 47(3), 375-382. https://doi.org/10.1248/cpb.47.375

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title = "The bakkenolides from the root of Petasites formosanus and their cytotoxicity",

abstract = "Thirty-two new bakkenolides, bakkenolides-Db (1) - Dh (7), -Fa (8), -Fb (9), -I (10) - M (14), -Na (15), -Nb (16), -O (17) - T (22), -Ua (23),-Ub (24),-V (25) - X (27), -Ya (28),-Yb (29), -Za (30), -Zb (31) and -III (32), from the roots of Petasites formosanus together with thirty known compounds were isolated. The structures were characterized by spectral analysis. The locations, C-1 and/or C-9 of bakkenolide skeleton, of the substituents, such as acetoxy, isobutyroyloxy and isovaleroyloxy groups, can be determined by the chemical shifts of their signals and the H-1 and/H-9 in the 1H-NMR spectra. The cytotoxicity was also discussed.",

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AU - Wu, Tian-Shung

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AU - Shi, Li Shian

AU - Liou, Meei Jen

AU - Li, Chia Ying

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AB - Thirty-two new bakkenolides, bakkenolides-Db (1) - Dh (7), -Fa (8), -Fb (9), -I (10) - M (14), -Na (15), -Nb (16), -O (17) - T (22), -Ua (23),-Ub (24),-V (25) - X (27), -Ya (28),-Yb (29), -Za (30), -Zb (31) and -III (32), from the roots of Petasites formosanus together with thirty known compounds were isolated. The structures were characterized by spectral analysis. The locations, C-1 and/or C-9 of bakkenolide skeleton, of the substituents, such as acetoxy, isobutyroyloxy and isovaleroyloxy groups, can be determined by the chemical shifts of their signals and the H-1 and/H-9 in the 1H-NMR spectra. The cytotoxicity was also discussed.

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