TY - JOUR
T1 - The bakkenolides from the root of Petasites formosanus and their cytotoxicity
AU - Wu, Tian Shung
AU - Kao, Mang San
AU - Wu, Pei Lin
AU - Lin, Ful Wen
AU - Shi, Li Shian
AU - Liou, Meei Jen
AU - Li, Chia Ying
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999/3
Y1 - 1999/3
N2 - Thirty-two new bakkenolides, bakkenolides-Db (1) - Dh (7), -Fa (8), -Fb (9), -I (10) - M (14), -Na (15), -Nb (16), -O (17) - T (22), -Ua (23),-Ub (24),-V (25) - X (27), -Ya (28),-Yb (29), -Za (30), -Zb (31) and -III (32), from the roots of Petasites formosanus together with thirty known compounds were isolated. The structures were characterized by spectral analysis. The locations, C-1 and/or C-9 of bakkenolide skeleton, of the substituents, such as acetoxy, isobutyroyloxy and isovaleroyloxy groups, can be determined by the chemical shifts of their signals and the H-1 and/H-9 in the 1H-NMR spectra. The cytotoxicity was also discussed.
AB - Thirty-two new bakkenolides, bakkenolides-Db (1) - Dh (7), -Fa (8), -Fb (9), -I (10) - M (14), -Na (15), -Nb (16), -O (17) - T (22), -Ua (23),-Ub (24),-V (25) - X (27), -Ya (28),-Yb (29), -Za (30), -Zb (31) and -III (32), from the roots of Petasites formosanus together with thirty known compounds were isolated. The structures were characterized by spectral analysis. The locations, C-1 and/or C-9 of bakkenolide skeleton, of the substituents, such as acetoxy, isobutyroyloxy and isovaleroyloxy groups, can be determined by the chemical shifts of their signals and the H-1 and/H-9 in the 1H-NMR spectra. The cytotoxicity was also discussed.
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U2 - 10.1248/cpb.47.375
DO - 10.1248/cpb.47.375
M3 - Article
C2 - 10400491
AN - SCOPUS:0032922025
VL - 47
SP - 375
EP - 382
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 3
ER -