TY - JOUR
T1 - The Burden of Ventricular Premature Complex Is Associated With Cardiovascular Mortality
AU - Lee, Po Tseng
AU - Huang, Ting Chun
AU - Huang, Mu Hsiang
AU - Hsu, Ling Wei
AU - Su, Pei Fang
AU - Liu, Yen Wen
AU - Hung, Meng Hsuan
AU - Liu, Ping Yen
N1 - Publisher Copyright:
Copyright © 2022 Lee, Huang, Huang, Hsu, Su, Liu, Hung and Liu.
PY - 2021
Y1 - 2021
N2 - Background: Ventricular premature complex (VPC) is one of the most common ventricular arrhythmias. The presence of VPC is associated with an increased risk of heart failure (HF). Method: We designed a single-center, retrospective, and large population-based cohort to clarify the role of VPC burden in long-term prognosis in Taiwan. We analyzed the database from the National Cheng Kung University Hospital-Electronic Medical Record (NCKUH-EMR) and NCKUH-Holter (NCKUH-Holter). A total of 19,527 patients who underwent 24-h Holter ECG monitoring due to palpitation, syncope, and clinical suspicion of arrhythmias were enrolled in this study. Results: The clinical outcome of interests involved 5.65% noncardiovascular death and 1.53% cardiovascular-specific deaths between 2011 and 2018. Multivariate Cox regression analysis, Fine and Gray's competing risk model, and propensity score matching demonstrated that both moderate (1,000–10,000/day) and high (>10,000/day) VPC burdens contributed to cardiovascular death in comparison with a low VPC burden (<1,000/day). Conclusion: A higher VPC burden via Holter ECG is an independent risk factor of cardiovascular mortality.
AB - Background: Ventricular premature complex (VPC) is one of the most common ventricular arrhythmias. The presence of VPC is associated with an increased risk of heart failure (HF). Method: We designed a single-center, retrospective, and large population-based cohort to clarify the role of VPC burden in long-term prognosis in Taiwan. We analyzed the database from the National Cheng Kung University Hospital-Electronic Medical Record (NCKUH-EMR) and NCKUH-Holter (NCKUH-Holter). A total of 19,527 patients who underwent 24-h Holter ECG monitoring due to palpitation, syncope, and clinical suspicion of arrhythmias were enrolled in this study. Results: The clinical outcome of interests involved 5.65% noncardiovascular death and 1.53% cardiovascular-specific deaths between 2011 and 2018. Multivariate Cox regression analysis, Fine and Gray's competing risk model, and propensity score matching demonstrated that both moderate (1,000–10,000/day) and high (>10,000/day) VPC burdens contributed to cardiovascular death in comparison with a low VPC burden (<1,000/day). Conclusion: A higher VPC burden via Holter ECG is an independent risk factor of cardiovascular mortality.
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U2 - 10.3389/fcvm.2021.797976
DO - 10.3389/fcvm.2021.797976
M3 - Article
AN - SCOPUS:85138511038
SN - 2297-055X
VL - 8
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 797976
ER -