The cellular immunophenotype expression of influenza A virus and influenza B virus infection in children

Ching Fen Shen, Tzong Shiann Ho, Shih Min Wang, Yu Ting Liao, Yu Shiang Hu, Huey Pin Tsai, Shun Hua Chen

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: The innate immune response is the primary defense against influenza virus infection. Methods: This is a prospective study carried out in children <18 years of age who were diagnosed with influenza A or influenza B infection. Demographic and clinical data, laboratory findings and cell immunophenotypes on first presentation were compared. Results: With respect to immunophenotype, influenza A infection resulted in a higher fraction of CD14+ and CD4+IL-17A+cells compared to children infected with influenza B. By contrast, influenza B infection resulted in a comparatively higher percentage of double-negative CD4CD8 lymphocyte subsets. Influenza A infection was associated with comparatively higher percentages of CD4+CD25highFoxp3+ and CD4+CD25lowFoxp3+ cells. By contrast, the percentage of CD8+CD25high and CD8+CD25low cells was similar among patients with influenza A infection and influenza B infection. Conclusions: An improved understanding of the fraction of regulatory T cells with influenza virus infections may provide further understandings on immune responses.

Original languageEnglish
Article number108548
JournalClinical Immunology
Volume219
DOIs
Publication statusPublished - 2020 Oct

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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