Abstract
There is continuous interest in developing manganese-based T1 contrast agents. While much effort has been made to synthesize manganese chelates, the development of manganese-based nanoparticle, particularly manganese oxides, as MRI contrast agents is burgeoning. In this report, sub-10-nm nanospheres, nanoplates, and nanocubes of Mn3O4 were synthesized and exhibited paramagnetic behavior at room temperature on the basis of superconducting quantum interference devices (SQUID) measurements. The surface Mn3+ passivated nanoplates examined by x-ray photoelectron spectroscopy (XPS) had the largest r1 relaxivity of the reported manganese oxide nanoparticles. The MR labeling assays of Mn3O4 nanoplate-treated A549 lung cancer cells showed that MR signals increased to 139% in T1-weighted images compared with untreated cells when the Mn ion concentration went down to 1.3 × 10-2 mm. A dark field illumination microscope was employed to monitor Mn3O4 nanoplates internalized into cells as a function of time.
Original language | English |
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Pages (from-to) | 4073-4078 |
Number of pages | 6 |
Journal | Biomaterials |
Volume | 31 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2010 May |
All Science Journal Classification (ASJC) codes
- Bioengineering
- Ceramics and Composites
- Biophysics
- Biomaterials
- Mechanics of Materials