TY - JOUR
T1 - The clinical use of small-dose tetracaine spinal anesthesia for transurethral prostatectomy
AU - Chen, Tsung Ying
AU - Tseng, Chia Chih
AU - Wang, Li Kai
AU - Tsai, Tong Ying
AU - Chen, Bing Shuo
AU - Chang, Chuan Lin
PY - 2001
Y1 - 2001
N2 - In a double-blinded study, we compared conventional dose tetracaine (8 mg), small-dose tetracaine (4 mg) with added fentanyl and epinephrine, and small-dose tetracaine (4 mg) with added fentanyl subarachnoid anesthesia. Forty-five patients scheduled for transurethral resection of prostate (TURP) under subarachnoid anesthesia were randomly assigned to Group 1 (8 mg hyperbaric tetracaine), Group 2 (4 mg hyperbaric tetracaine, 10 μg fentanyl, and 0.2 mg epinephrine), and Group 3 (4 mg hyperbaric tetracaine, 10 μg fentanyl, and 0.2 mL saline). Evaluations were performed after spinal anesthesia. Subarachnoid block was successful in all patients except one in Group 1, who required general anesthesia by mask. The median peak sensory levels 10 min after the induction of spinal anesthesia in Group 1 was T8, which was significantly higher than Group 2 and Group 3 (P < 0.05). The time of sensory and motor recovery in Group 3 was less than in Groups 1 and 2 (P < 0.05). Hypotension was observed in four patients in Group 1 and none in Groups 2 and 3. We conclude that small-dose 4-mg hyperbaric tetracaine plus 10 μg fentanyl might provide adequate anesthesia and fewer side effects for TURP when compared with the conventional (8 mg) dose.
AB - In a double-blinded study, we compared conventional dose tetracaine (8 mg), small-dose tetracaine (4 mg) with added fentanyl and epinephrine, and small-dose tetracaine (4 mg) with added fentanyl subarachnoid anesthesia. Forty-five patients scheduled for transurethral resection of prostate (TURP) under subarachnoid anesthesia were randomly assigned to Group 1 (8 mg hyperbaric tetracaine), Group 2 (4 mg hyperbaric tetracaine, 10 μg fentanyl, and 0.2 mg epinephrine), and Group 3 (4 mg hyperbaric tetracaine, 10 μg fentanyl, and 0.2 mL saline). Evaluations were performed after spinal anesthesia. Subarachnoid block was successful in all patients except one in Group 1, who required general anesthesia by mask. The median peak sensory levels 10 min after the induction of spinal anesthesia in Group 1 was T8, which was significantly higher than Group 2 and Group 3 (P < 0.05). The time of sensory and motor recovery in Group 3 was less than in Groups 1 and 2 (P < 0.05). Hypotension was observed in four patients in Group 1 and none in Groups 2 and 3. We conclude that small-dose 4-mg hyperbaric tetracaine plus 10 μg fentanyl might provide adequate anesthesia and fewer side effects for TURP when compared with the conventional (8 mg) dose.
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U2 - 10.1097/00000539-200104000-00040
DO - 10.1097/00000539-200104000-00040
M3 - Article
C2 - 11273943
AN - SCOPUS:0035085451
SN - 0003-2999
VL - 92
SP - 1020
EP - 1023
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 4
ER -